The chemistry of 2-aminocycloalkanecarboxylic acids

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Abstract

The synthesis and transformations of 2-aminocycloalkanecarboxylic acids were discussed. The resolution of the racemates by diastereomer separation and biocatalyzed transformations were studied. It was found that the selective reductive aminations of β-ketoesters via enamines resulted into the accurate ratios of cis and trans diastereomers. The synthesis of 2-aminocycloalkanecarboxylic acids from 1,2-dicarboxylic acids derivatives by rearrangements was also elaborated.

Original languageEnglish
Pages (from-to)2181-2204
Number of pages24
JournalChemical reviews
Volume101
Issue number7
DOIs
Publication statusPublished - Jul 1 2001

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ASJC Scopus subject areas

  • Chemistry(all)

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