The chemical and pharmacological importance of morphine analogues

S. Fürst, S. Hosztafi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The object of this review is to summarize the efforts which resulted in the discovery of therapeutically useful morphine-like drugs. The search for new analgesics can be divided into three stages: a) search for analgesics with high efficacy and reduced unwanted side-effects; b) understanding of structure-activity relationships; c) studies on the mechanism of pain perception and its alleviation by investigation of the pharmacology of opioids. An immense body of literature has been produced on the syntheses of thousands of new compounds which resulted in the development of detailed structure-activity relationships. The physical and psychologic dependence of opioid analgesics also facilitated investigators to solve the problem of the separation of strong analgesia from addiction liability. In the past decades more mixed agonist-antagonist analgesics, pure antagonists devoid of agonist action and potent opioids like the 6, 14-ethenomorphinan derivatives were developed. Naloxone, Naltrexone, Buprenorphine and Pentazocine are the outstanding representatives which are introduced into clinical therapy.

Original languageEnglish
Pages (from-to)3-44
Number of pages42
JournalActa Physiologica Hungarica
Volume95
Issue number1
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Morphine
Opioid Analgesics
Analgesics
Pharmacology
Structure-Activity Relationship
Pentazocine
Naltrexone
Pain Perception
Analgesia
Research Personnel
Pharmaceutical Preparations
Therapeutics
Naloxone Drug Combination Buprenorphine

Keywords

  • Mixed agonist-antagonists
  • Morphine
  • Opioid analgesics
  • Opioid antagonists
  • Partial agonists
  • Structure-activity relationships

ASJC Scopus subject areas

  • Physiology

Cite this

The chemical and pharmacological importance of morphine analogues. / Fürst, S.; Hosztafi, S.

In: Acta Physiologica Hungarica, Vol. 95, No. 1, 03.2008, p. 3-44.

Research output: Contribution to journalArticle

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