The cerebrocortical microcirculatory effect of nitric oxide synthase blockade is dependent upon baseline red blood cell flow in the rat

Zsombor Lacza, Benedek Erdos, Christoph Görlach, Michael Wahl, Péter Sándor, Zoltán Benyó

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Abstract

The effects of nitric oxide synthase (NOS) blockade on the cerebrocortical microcirculation were investigated under physiological conditions in anesthetized ventilated rats using laser-Doppler (LD) flowmetry. LD flow values of the parietal cortex were determined before and after systemic administration of the NOS inhibitor N(G)-nitro-L-arginine- methyl-esther. NOS blockade reduced the LD flow significantly and the magnitude of the reduction was in close correlation with the baseline value. Synchronized sinus-wave-like LD flow oscillations were observed frequently after NOS inhibition and their appearance was also dependent on the high baseline flow values. These results indicate marked, baseline-dependent differences in the cerebrocortical blood flow response to the inhibition of the nitric oxide pathway, and may suggest that areas with high resting red blood cell flow express high NOS activity. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalNeuroscience Letters
Volume291
Issue number2
DOIs
Publication statusPublished - Sep 15 2000

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Keywords

  • Cerebral blood flow
  • Cerebral cortex
  • Laser-Doppler flowmetry
  • Microcirculation
  • Nitric oxide
  • Rat
  • Vasomotion

ASJC Scopus subject areas

  • Neuroscience(all)

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