The capsaicin analogue 'resiniferatoxin' protects against injury by aspirin and indomethacin in the rat stomach

O. M E Abdel-Salam, J. Szolcsányi, G. Mózsik

Research output: Contribution to journalArticle

Abstract

The effect of the capsaicin analogue 'resiniferatoxin' on gastric mucosal injury caused by topical acidified aspirin, intragastric indomethacin, subcutaneous aspirin and subcutaneous indomethacin was studied in pylorus-ligated rats. The animals were sacrificed 4 hours after pylorus ligation and drug administration and additionally, in the studies with topical acidified aspirin, at 1 and 2 hours. Resiniferatoxin (RTX) administered intragastrically at time of pylorus-ligation significantly prevented injury by intragastric, subcutaneous indomethacin or systemic aspirin in the 4 hour pylorus-ligated rat. Resiniferatoxin significantly protected against topical acidified aspirin for a period of only 1 hour. The protective effect of resiniferatoxin against indomethacin-induced injury was not evident after bilateral subdiaphragmatic vagotomy. It is concluded that RTX exerts gastric protective effects in the rat stomach.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalHellenic Journal of Gastroenterology
Volume8
Issue number2
Publication statusPublished - 1995

Fingerprint

Capsaicin
Indomethacin
Aspirin
Pylorus
Stomach
Wounds and Injuries
Ligation
Vagotomy
resiniferatoxin
Pharmaceutical Preparations

Keywords

  • Aspirin
  • Gastric mucosal blood flow
  • Indomethacin
  • Resiniferatoxin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{083bcedf02684e7e9aeeb0c536f0dbfd,
title = "The capsaicin analogue 'resiniferatoxin' protects against injury by aspirin and indomethacin in the rat stomach",
abstract = "The effect of the capsaicin analogue 'resiniferatoxin' on gastric mucosal injury caused by topical acidified aspirin, intragastric indomethacin, subcutaneous aspirin and subcutaneous indomethacin was studied in pylorus-ligated rats. The animals were sacrificed 4 hours after pylorus ligation and drug administration and additionally, in the studies with topical acidified aspirin, at 1 and 2 hours. Resiniferatoxin (RTX) administered intragastrically at time of pylorus-ligation significantly prevented injury by intragastric, subcutaneous indomethacin or systemic aspirin in the 4 hour pylorus-ligated rat. Resiniferatoxin significantly protected against topical acidified aspirin for a period of only 1 hour. The protective effect of resiniferatoxin against indomethacin-induced injury was not evident after bilateral subdiaphragmatic vagotomy. It is concluded that RTX exerts gastric protective effects in the rat stomach.",
keywords = "Aspirin, Gastric mucosal blood flow, Indomethacin, Resiniferatoxin",
author = "Abdel-Salam, {O. M E} and J. Szolcs{\'a}nyi and G. M{\'o}zsik",
year = "1995",
language = "English",
volume = "8",
pages = "126--131",
journal = "Annals of Gastroenterology",
issn = "1108-7471",
publisher = "Hellenic Society of Gastroenterology",
number = "2",

}

TY - JOUR

T1 - The capsaicin analogue 'resiniferatoxin' protects against injury by aspirin and indomethacin in the rat stomach

AU - Abdel-Salam, O. M E

AU - Szolcsányi, J.

AU - Mózsik, G.

PY - 1995

Y1 - 1995

N2 - The effect of the capsaicin analogue 'resiniferatoxin' on gastric mucosal injury caused by topical acidified aspirin, intragastric indomethacin, subcutaneous aspirin and subcutaneous indomethacin was studied in pylorus-ligated rats. The animals were sacrificed 4 hours after pylorus ligation and drug administration and additionally, in the studies with topical acidified aspirin, at 1 and 2 hours. Resiniferatoxin (RTX) administered intragastrically at time of pylorus-ligation significantly prevented injury by intragastric, subcutaneous indomethacin or systemic aspirin in the 4 hour pylorus-ligated rat. Resiniferatoxin significantly protected against topical acidified aspirin for a period of only 1 hour. The protective effect of resiniferatoxin against indomethacin-induced injury was not evident after bilateral subdiaphragmatic vagotomy. It is concluded that RTX exerts gastric protective effects in the rat stomach.

AB - The effect of the capsaicin analogue 'resiniferatoxin' on gastric mucosal injury caused by topical acidified aspirin, intragastric indomethacin, subcutaneous aspirin and subcutaneous indomethacin was studied in pylorus-ligated rats. The animals were sacrificed 4 hours after pylorus ligation and drug administration and additionally, in the studies with topical acidified aspirin, at 1 and 2 hours. Resiniferatoxin (RTX) administered intragastrically at time of pylorus-ligation significantly prevented injury by intragastric, subcutaneous indomethacin or systemic aspirin in the 4 hour pylorus-ligated rat. Resiniferatoxin significantly protected against topical acidified aspirin for a period of only 1 hour. The protective effect of resiniferatoxin against indomethacin-induced injury was not evident after bilateral subdiaphragmatic vagotomy. It is concluded that RTX exerts gastric protective effects in the rat stomach.

KW - Aspirin

KW - Gastric mucosal blood flow

KW - Indomethacin

KW - Resiniferatoxin

UR - http://www.scopus.com/inward/record.url?scp=0029161864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029161864&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 126

EP - 131

JO - Annals of Gastroenterology

JF - Annals of Gastroenterology

SN - 1108-7471

IS - 2

ER -