The effect of the capsaicin analogue 'resiniferatoxin' on gastric mucosal injury caused by topical acidified aspirin, intragastric indomethacin, subcutaneous aspirin and subcutaneous indomethacin was studied in pylorus-ligated rats. The animals were sacrificed 4 hours after pylorus ligation and drug administration and additionally, in the studies with topical acidified aspirin, at 1 and 2 hours. Resiniferatoxin (RTX) administered intragastrically at time of pylorus-ligation significantly prevented injury by intragastric, subcutaneous indomethacin or systemic aspirin in the 4 hour pylorus-ligated rat. Resiniferatoxin significantly protected against topical acidified aspirin for a period of only 1 hour. The protective effect of resiniferatoxin against indomethacin-induced injury was not evident after bilateral subdiaphragmatic vagotomy. It is concluded that RTX exerts gastric protective effects in the rat stomach.
|Number of pages||6|
|Journal||Hellenic Journal of Gastroenterology|
|Publication status||Published - Jan 1 1995|
- Gastric mucosal blood flow
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