The capsaicin analogue 'resiniferatoxin' protects against injury by aspirin and indomethacin in the rat stomach

O. M.E. Abdel-Salam, J. Szolcsanyi, Gy Mozsik

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The effect of the capsaicin analogue 'resiniferatoxin' on gastric mucosal injury caused by topical acidified aspirin, intragastric indomethacin, subcutaneous aspirin and subcutaneous indomethacin was studied in pylorus-ligated rats. The animals were sacrificed 4 hours after pylorus ligation and drug administration and additionally, in the studies with topical acidified aspirin, at 1 and 2 hours. Resiniferatoxin (RTX) administered intragastrically at time of pylorus-ligation significantly prevented injury by intragastric, subcutaneous indomethacin or systemic aspirin in the 4 hour pylorus-ligated rat. Resiniferatoxin significantly protected against topical acidified aspirin for a period of only 1 hour. The protective effect of resiniferatoxin against indomethacin-induced injury was not evident after bilateral subdiaphragmatic vagotomy. It is concluded that RTX exerts gastric protective effects in the rat stomach.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalHellenic Journal of Gastroenterology
Issue number2
Publication statusPublished - Jan 1 1995



  • Aspirin
  • Gastric mucosal blood flow
  • Indomethacin
  • Resiniferatoxin

ASJC Scopus subject areas

  • Gastroenterology

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