The calcineurin activity and MCIP1.4 mRNA levels are increased by innervation in regenerating soleus muscle

Rita Fenyvesi, Gábor Rácz, Frank Wuytack, Erno Zádor

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The level of active subunit of calcineurin and the calcineurin (Cn) enzyme activity are increased in innervated but not in denervated slow type regenerating skeletal soleus muscle. These nerve-dependent increases were not accompanied by similar increases in the mRNA levels. The changes in the mRNA level of the modulatory calcineurin interacting protein, MCIP1.4, reflected the calcineurin activity and did not increase in denervated regenerating muscles compared to the innervated regenerating controls. The increases in Cn activity and in MCIP1.4 mRNA levels occurred before the switch from fast to slow-type myosin heavy chain isoforms, a phenomenon similarly known to be dependent on innervation. This highlights the role of mediators, acting between the nerve and calcineurin, in the formation of slow fiber identity.

Original languageEnglish
Pages (from-to)599-605
Number of pages7
JournalBiochemical and biophysical research communications
Volume320
Issue number2
DOIs
Publication statusPublished - Jul 23 2004

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Keywords

  • Calcineurin
  • MCIP1.4
  • Myosin heavy chain
  • Regeneration
  • SERCA

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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