The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia

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We investigated a novel polymorphism of single nucleotide substitution (C270T) of the brain-derived neurotrophic factor (BDNF) gene in schizophrenia patients (n=101) and in controls (n=68). The frequency of the C/T genotype and the T allele were significantly higher in the schizophrenia patients (25.7% and 13.9%, respectively) compared with the controls (5.9% and 2.9%). There were no significant differences in Positive and Negative Symptom Scale (PANSS) items and Global Assessment of Functioning (GAF) scores between the patients with C/C and C/T genotypes. Further studies are warranted to elucidate the significance of this finding in the pathophysiology of schizophrenia.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalSchizophrenia Research
Issue number1
Publication statusPublished - Dec 1 2003



  • Association study
  • Brain-derived neurotrophic factor (BDNF)
  • Neurodevelopmental hypothesis
  • Neurotrophic factors
  • Polymorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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