The brain-immune-gut triangle: Innate immunity in psychiatric and neurological disorders

Attila Szabo, E. Rajnavolgyi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The communication between the immune and central nervous systems has been known for decades. Although the biological rules and complexity of the neuroimmune axis is yet to be clarified, in the modern era of immunology and clinical neurosciences it has become a dynamically evolving paradigm. In this review we trace the major findings of this emerging field with a special focus on innate immune cells and their phylogenetically conserved receptors, in line with their role in various psychiatric and neurological diseases. A particular interest will be given to monocytes, macrophages/microglia, dendritic cells, Toll-like and RIG-I-like receptors as well as their contribution to inflammation and other pathological processes in the CNS. Uncovering immunological mechanisms in the context of brain functions emerges as a promising avenue for future therapeutic interventions in various, still incurable ailments such as Alzheimer's disease, schizophrenia, or different mood disorders such as major depression or bipolar disorder. We propose new perspectives for the pharmacological modification of innate immune cells and their response to inflammatory cues in the brain. A holistic concept of studying the gut-brain-immune triangle is also suggested to bring up novel approaches in immunology, gastroenterology, psychiatry and neurology.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalCurrent Immunology Reviews
Volume9
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Nervous System Diseases
Innate Immunity
Psychiatry
Allergy and Immunology
Brain
Microglia
Gastroenterology
Pathologic Processes
Neurology
Neurosciences
Mood Disorders
Bipolar Disorder
Dendritic Cells
Cues
Monocytes
Schizophrenia
Alzheimer Disease
Central Nervous System
Macrophages
Communication

Keywords

  • Gut microbiota
  • Gut-brain axis
  • Innate immunity
  • Neuroimmunology
  • Pattern recognition receptors
  • Psychoneuroimmunology

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The brain-immune-gut triangle : Innate immunity in psychiatric and neurological disorders. / Szabo, Attila; Rajnavolgyi, E.

In: Current Immunology Reviews, Vol. 9, No. 4, 2013, p. 241-248.

Research output: Contribution to journalArticle

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