A myelodysplasia biológiája.

Translated title of the contribution: The biology of myelodysplastic syndromes

Gergely Varga, F. Uher

Research output: Contribution to journalArticle

Abstract

In the past 10 years a large amount of data has been published with respect to myelodysplasia. However, this newly emerged data, to date, has not been integrated into an all encompassing cohesive concept. The more knowledge we have about this illness to more precise diagnostic classifications, prognostications and eventually curative treatment modalities are possible. The ineffective haemopoiesis that is a hallmark of the disease may be explained by the apoptosis, hence antiapoptotic therapy, it appears, in some cases results in improvement. It is known that the malfunction of the mitochondria is responsible for accumulating the iron in sideroblastic anemia. The same mitochondrial malfunction may also be a factor in the development and progression of the non-sideroblastic forms of myelodysplasia as well. Promising research is on the way in examining the interaction between stroma cells of the bone marrow and the stem cells. Several publications study the hypothesis that the stroma also plays a significant role in the development of myelodysplasia clone. This role may be a causative one or perhaps a more passive/permissive one. This paper attempts to provide an overview of the newly emerged data, published in the most recent years, concerning myelodysplasia.

Original languageHungarian
Pages (from-to)1163-1170
Number of pages8
JournalOrvosi Hetilap
Volume145
Issue number22
Publication statusPublished - May 30 2004

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Sideroblastic Anemia
Myelodysplastic Syndromes
Bone Marrow Cells
Publications
Mitochondria
Stem Cells
Iron
Clone Cells
Apoptosis
Research
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Varga, G., & Uher, F. (2004). A myelodysplasia biológiája. Orvosi Hetilap, 145(22), 1163-1170.

A myelodysplasia biológiája. / Varga, Gergely; Uher, F.

In: Orvosi Hetilap, Vol. 145, No. 22, 30.05.2004, p. 1163-1170.

Research output: Contribution to journalArticle

Varga, G & Uher, F 2004, 'A myelodysplasia biológiája.', Orvosi Hetilap, vol. 145, no. 22, pp. 1163-1170.
Varga G, Uher F. A myelodysplasia biológiája. Orvosi Hetilap. 2004 May 30;145(22):1163-1170.
Varga, Gergely ; Uher, F. / A myelodysplasia biológiája. In: Orvosi Hetilap. 2004 ; Vol. 145, No. 22. pp. 1163-1170.
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