Az afrikai sertéspestis VÍrusának biológiája

Irodalmi összefoglaló

Translated title of the contribution: The biology of African swine fever: Literature review

Mészáros István, Olasz Ferenc, Tamás Vivien, A. Bálint, Z. Zádori

Research output: Contribution to journalArticle

Abstract

Starting in 2007, the African swine fever (ASF) advanced seemingly unstoppably from the Caucasus region toward the western part of Europe, and in 2018 it reached Hungary. In the lack of vaccine, the spread of ASF constitutes the biggest economical and animal health threat to the Hungarian and worldwide swine industry. The African swine fever virus (ASFV) is the causative agent of the disease. ASFV is an enveloped virus with a large (170-190 kilo base pair) double stranded DNA genome that contains around 200 open reading frames. The virus is the sole member of the Asfaviridae family. ASFV has high genetic and antigenic variability, so far 23 genotypes and at least 8 serotypes were identified. It is the only known DNA arbovirus, its natural hosts are soft ticks belonging to the genus Ornithodoros, and African wild pig species (common warthog (Phacocheorus africanus) and bushpig (Potamochoerus larvatus)). In domestic pigs (Sus scrofa) the virus replicates mainly in macrophages. ASFV utilizes both clathrin-mediated endocytosis and macropinocytosis to enter the macrophages and it replicates in the cytoplasm. At least fourteen ASFV protein was shown to contain strong immunodeterminant epitops and some of them are able to induce at least partially neutralizing antibodies. It seems that cellular immunity, natural killer cells and CD8+ lymphocytes play crucial role in the induction of protective immunity against ASFV. In this paper the authors present the most essential biological knowledge about the ASFV and review its entry, replication and immunology in more details.

Original languageHungarian
Pages (from-to)47-54
Number of pages8
JournalMagyar Allatorvosok Lapja
Volume141
Issue number1
Publication statusPublished - Jan 1 2019

Fingerprint

African Swine Fever
African Swine Fever Virus
African swine fever virus
African swine fever
Biological Sciences
Sus scrofa
Swine
Viruses
viruses
macrophages
Argasidae
Ornithodoros
Macrophages
pork industry
Phacochoerus aethiopicus
Arboviruses
Antigenic Variation
clathrin
Clathrin
arboviruses

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Az afrikai sertéspestis VÍrusának biológiája : Irodalmi összefoglaló. / István, Mészáros; Ferenc, Olasz; Vivien, Tamás; Bálint, A.; Zádori, Z.

In: Magyar Allatorvosok Lapja, Vol. 141, No. 1, 01.01.2019, p. 47-54.

Research output: Contribution to journalArticle

István, Mészáros ; Ferenc, Olasz ; Vivien, Tamás ; Bálint, A. ; Zádori, Z. / Az afrikai sertéspestis VÍrusának biológiája : Irodalmi összefoglaló. In: Magyar Allatorvosok Lapja. 2019 ; Vol. 141, No. 1. pp. 47-54.
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