The biological role of lactoferrin.

K. Német, I. Simonovits

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Lactoferrin (LF)--in various quantities--is present in human milk, secretions and polymorphonuclear neutrophils (PMN). LF's significance lies in its bacteriostatic effect on its environment. Probably it prevents bacterial uptake of iron, leads to damage of bacteria and during phagocytosis helps the organism to combat pathogens. Most likely it regulates iron absorption, and during inflammation it takes part in the plasma iron transport. LF is believed to play an important role in the regulation of granulopoiesis in the bone-marrow. From its biological effects it appears that plasma LF determinations may be useful in the clinical diagnosis of leukaemia and other malignant diseases, as well as in the study of iron metabolism.

Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalHaematologia
Volume18
Issue number1
Publication statusPublished - Jan 1 1985

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ASJC Scopus subject areas

  • Hematology

Cite this

Német, K., & Simonovits, I. (1985). The biological role of lactoferrin. Haematologia, 18(1), 3-12.