Az ösztrogénmetabolom biológiai és klinikai jelentosége lokális folyamatokban

Translated title of the contribution: The biological and clinical relevance of estrogen metabolome

Kovács Krisztián, B. Vásárhelyi, Mészáros Katalin, A. Patócs, Karvaly Gellért

Research output: Contribution to journalArticle

Abstract

Considerable knowledge has been gathered on the physiological role of estrogens. However, fairly little information is available on the role of compounds produced in the breakdown process of estrone and estradiol wich may play a role in various diseases associated with estrogen impact. To date, approximately 15 extragonadal estrogen-related compounds have been identified. These metabolites may exert protective, or, instead, pro-inflammatory and/or prooncogenic activity in a tissue-specific manner. Systemic and local estrogen metabolite levels are not necesserily correlated, which may promote the diagnostic significance of the locally produced estrogen metabolites in the future. The aim of the present study is a bibliographic review of the extragonadal metabolome in peripheral tissues, and to highlight the role of the peripheral tissue homeostasis of estrogens as well as the non-hormonal biological activity and clinical significance of the estrogen metabolome.

Translated title of the contributionThe biological and clinical relevance of estrogen metabolome
Original languageHungarian
Pages (from-to)929-937
Number of pages9
JournalOrvosi Hetilap
Volume158
Issue number24
DOIs
Publication statusPublished - Jun 1 2017

ASJC Scopus subject areas

  • Medicine(all)

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