The beneficial effects of nettle supplementation and exercise on brain lesion and memory in rat

Anna Toldy, Mustafa Atalay, Krisztián Stadler, M. Sasvári, J. Jakus, Kyung J. Jung, Hae Y. Chung, C. Nyakas, Z. Radák

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Regular swimming and phytotherapeutic supplementation are assumed to alleviate the severity of neurodegeneration leading to dementia. The effect of swimming training and that of enriched lab chow containing 1% (w/w) dried nettle (Urtica dioica) leaf on the prevention of severity of brain injury caused by N-methyl-d-aspartate (NMDA) lesion in Wistar rats were investigated. Nettle supplementation and regular swimming exercise seem to improve the adverse effect of brain injury caused by NMDA lesion assessed by passive avoidance test and open-field test. Nettle supplementation decreases the level of reactive oxygen species, measured by electron paramagnetic resonance, and the DNA-binding activity of NF-κB. The data reveal that nettle supplementation has an effective antioxidant role, down-regulates the inflammatory transcription factors and could also promote learning performance in the brain. Regular swimming increases the concentration of reactive species in the cerebellum and alters the activity of transcription factors toward inflammation. The additive effect of the two treatments was more profound in the down-regulation of inflammatory transcription processes in NMDA lesion.

Original languageEnglish
Pages (from-to)974-981
Number of pages8
JournalJournal of Nutritional Biochemistry
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Rats
Brain
Aspartic Acid
Data storage equipment
Brain Injuries
Transcription Factors
Down-Regulation
Urtica dioica
Electron Spin Resonance Spectroscopy
Transcription
Cerebellum
Paramagnetic resonance
Dementia
Wistar Rats
Reactive Oxygen Species
Antioxidants
Learning
Inflammation
Swimming
DNA

Keywords

  • Brain
  • Neurodegeneration
  • Neurotrophins
  • NMDA lesion
  • Oxidative stress
  • Stinging nettle
  • Swimming exercise
  • Transcription factors

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

The beneficial effects of nettle supplementation and exercise on brain lesion and memory in rat. / Toldy, Anna; Atalay, Mustafa; Stadler, Krisztián; Sasvári, M.; Jakus, J.; Jung, Kyung J.; Chung, Hae Y.; Nyakas, C.; Radák, Z.

In: Journal of Nutritional Biochemistry, Vol. 20, No. 12, 12.2009, p. 974-981.

Research output: Contribution to journalArticle

Toldy, Anna ; Atalay, Mustafa ; Stadler, Krisztián ; Sasvári, M. ; Jakus, J. ; Jung, Kyung J. ; Chung, Hae Y. ; Nyakas, C. ; Radák, Z. / The beneficial effects of nettle supplementation and exercise on brain lesion and memory in rat. In: Journal of Nutritional Biochemistry. 2009 ; Vol. 20, No. 12. pp. 974-981.
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