The behavioural depression of hippocampal kindled rats is attenuated by subcutaneous and intracerebroventricular naltrexone

G. A. Cottrell, C. Nyakas, B. Bohus

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. Two questions were asked: Does naltrexone attenuate the behavioural depression (BD) in other models of limbic epilepsy besides amygdala kindling? Does intracerebroventricular (ICV) administration produce the same effects as subcutaneous injection i.e., attenuation of the BD. 2. Male wistar rats with bipolar electrodes implanted bilaterally in the dorsal hippocampus and a metal cannula in the lateral ventricle were kindled through 1 electrode and EEG recorded through the contralateral electrode. 3. Subcutaneous (sc) and ICV naltrexone administration attenuated the BD of hippocampal kindled rats. 4. These results further implicate the brain opioid system in the postictal phase of kindling and possibly epilepsy.

Original languageEnglish
Pages (from-to)673-676
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume8
Issue number4-6
DOIs
Publication statusPublished - 1984

Fingerprint

Naltrexone
Epilepsy
Electrodes
Implanted Electrodes
Lateral Ventricles
Subcutaneous Injections
Amygdala
Opioid Analgesics
Wistar Rats
Electroencephalography
Hippocampus
Metals
Brain
Cannula

Keywords

  • amygdala kindling
  • behavioural depression
  • epilepsy
  • hippocampal kindling
  • naltrexone
  • opiate receptors

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

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abstract = "1. Two questions were asked: Does naltrexone attenuate the behavioural depression (BD) in other models of limbic epilepsy besides amygdala kindling? Does intracerebroventricular (ICV) administration produce the same effects as subcutaneous injection i.e., attenuation of the BD. 2. Male wistar rats with bipolar electrodes implanted bilaterally in the dorsal hippocampus and a metal cannula in the lateral ventricle were kindled through 1 electrode and EEG recorded through the contralateral electrode. 3. Subcutaneous (sc) and ICV naltrexone administration attenuated the BD of hippocampal kindled rats. 4. These results further implicate the brain opioid system in the postictal phase of kindling and possibly epilepsy.",
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T1 - The behavioural depression of hippocampal kindled rats is attenuated by subcutaneous and intracerebroventricular naltrexone

AU - Cottrell, G. A.

AU - Nyakas, C.

AU - Bohus, B.

PY - 1984

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N2 - 1. Two questions were asked: Does naltrexone attenuate the behavioural depression (BD) in other models of limbic epilepsy besides amygdala kindling? Does intracerebroventricular (ICV) administration produce the same effects as subcutaneous injection i.e., attenuation of the BD. 2. Male wistar rats with bipolar electrodes implanted bilaterally in the dorsal hippocampus and a metal cannula in the lateral ventricle were kindled through 1 electrode and EEG recorded through the contralateral electrode. 3. Subcutaneous (sc) and ICV naltrexone administration attenuated the BD of hippocampal kindled rats. 4. These results further implicate the brain opioid system in the postictal phase of kindling and possibly epilepsy.

AB - 1. Two questions were asked: Does naltrexone attenuate the behavioural depression (BD) in other models of limbic epilepsy besides amygdala kindling? Does intracerebroventricular (ICV) administration produce the same effects as subcutaneous injection i.e., attenuation of the BD. 2. Male wistar rats with bipolar electrodes implanted bilaterally in the dorsal hippocampus and a metal cannula in the lateral ventricle were kindled through 1 electrode and EEG recorded through the contralateral electrode. 3. Subcutaneous (sc) and ICV naltrexone administration attenuated the BD of hippocampal kindled rats. 4. These results further implicate the brain opioid system in the postictal phase of kindling and possibly epilepsy.

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KW - behavioural depression

KW - epilepsy

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KW - naltrexone

KW - opiate receptors

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