The "B space" of mitochondrial phosphorylation

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22 Citations (Scopus)

Abstract

It was recently shown that, in progressively depolarizing mitochondria, the F 0-F 1 ATP synthase and the adenine nucleotide translocase (ANT) may change directionality independently from each other (Chinopoulos et al. [2010] FASEB J. 24:2405). When the membrane potentials at which these two molecular entities reverse directionality, termed reversal potential (Erev), are plotted as a function of matrix ATP/ADP ratio, an area of the plot is bracketed by the Erev-ATPase and the Erev-ANT, which we call "B space". Both reversal potentials are dynamic, in that they depend on the fluctuating values of the participating reactants; however, Erev-ATPase is almost always more negative than Erev-ANT. Here we review the conditions that define the boundaries of the "B space". Emphasis is placed on the role of matrix substrate-level phosphorylation, because during metabolic compromise this mechanism could maintain mitochondrial membrane potential and prevent the influx of cytosolic ATP destined for hydrolysis by the reversed F 0-F 1 ATP synthase.

Original languageEnglish
Pages (from-to)1897-1904
Number of pages8
JournalJournal of Neuroscience Research
Volume89
Issue number12
DOIs
Publication statusPublished - Dec 1 2011

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Keywords

  • ANT
  • F -F ATP synthase
  • Oxidative phosphorylation
  • Phosphate
  • Substrate-level phosphorylation
  • Succinyl-CoA ligase
  • Systems biology

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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