The autophagic roles of Rab small GTPases and their upstream regulators: A review

Zsuzsanna Szatmári, M. Sass

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Macroautophagy is an evolutionarily conserved degradative process of eukaryotic cells. Double-membrane vesicles called autophagosomes sequester portions of cytoplasm and undergo fusion with the endolysosomal pathway in order to degrade their content. There is growing evidence that members of the small GTPase RAB protein family - the well - known regulators of membrane trafficking and fusion events-play key roles in the regulation of the autophagic process. Despite numerous studies focusing on the functions of RAB proteins in autophagy, the importance of their upstream regulators in this process emerged only in the past few years. In this review, we summarize recent advances on the effects of RABs and their upstream modulators in the regulation of autophagy. Moreover, we discuss how impairment of these proteins alters the autophagic process leading to several generally known human diseases.

Original languageEnglish
Pages (from-to)1154-1166
Number of pages13
JournalAutophagy
Volume10
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

rab GTP-Binding Proteins
Monomeric GTP-Binding Proteins
Autophagy
Proteins
Membrane Fusion
Eukaryotic Cells
Cytoplasm
Membranes

Keywords

  • Autophagy
  • GAP
  • GEF
  • RAB
  • Small GTPases

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

The autophagic roles of Rab small GTPases and their upstream regulators : A review. / Szatmári, Zsuzsanna; Sass, M.

In: Autophagy, Vol. 10, No. 7, 2014, p. 1154-1166.

Research output: Contribution to journalArticle

Szatmári, Zsuzsanna ; Sass, M. / The autophagic roles of Rab small GTPases and their upstream regulators : A review. In: Autophagy. 2014 ; Vol. 10, No. 7. pp. 1154-1166.
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