The association of the carrier state of the tumor necrosis factor-α (TNFα) -308A allele with the duration of oxygen supplementation in preterm neonates

Géza Bokodi, András Treszl, László Derzbach, Ádám Balogh, B. Vásárhelyi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background. High levels of inflammatory cytokines lead to lung damage in premature newborns. We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the length of oxygen supplementation. Methods. We genotyped 123 very low birth weight (VLBW) infants for the tumour necrosis factor (TNF)- α G -308A, interleukin (IL)-1β C 3954T, IL-6 G -174C and IL-10 G -1082A SNPs. Genomic DNA was isolated from remnant dried blood samples from the neonates. We tested the association between SNPs and ventilation characteristics using a stepwise multiple regression analysis model. Results. The carrier state of the TNF-α G -308A allele was associated with a 40-hour longer period of mechanical ventilation (p=0.004) and, on average, an additional 36 hours of oxygen supplementation (p=0.0008). The association was significant after its adjustment for perinatal risk factors for lung damage. Conclusions. The TNF-α G 308A genotype - which is associated with increased TNF-α levels - might influence the supplemental oxygen requirement of VLBW infants.

Original languageEnglish
Pages (from-to)78-80
Number of pages3
JournalEuropean Cytokine Network
Volume16
Issue number1
Publication statusPublished - Jan 2005

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Carrier State
Tumor Necrosis Factor-alpha
Alleles
Newborn Infant
Oxygen
Single Nucleotide Polymorphism
Very Low Birth Weight Infant
Cytokines
Lung
Polymorphism
Interleukin-1
Artificial Respiration
Innate Immunity
Regression analysis
Interleukin-10
Ventilation
Interleukin-6
Blood
Nucleotides
Genes

Keywords

  • Cytokine
  • Genetic polymorphism
  • Oxygen supplementation
  • Preterm neonate
  • Tumour necrosis factor alpha

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

The association of the carrier state of the tumor necrosis factor-α (TNFα) -308A allele with the duration of oxygen supplementation in preterm neonates. / Bokodi, Géza; Treszl, András; Derzbach, László; Balogh, Ádám; Vásárhelyi, B.

In: European Cytokine Network, Vol. 16, No. 1, 01.2005, p. 78-80.

Research output: Contribution to journalArticle

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AU - Balogh, Ádám

AU - Vásárhelyi, B.

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N2 - Background. High levels of inflammatory cytokines lead to lung damage in premature newborns. We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the length of oxygen supplementation. Methods. We genotyped 123 very low birth weight (VLBW) infants for the tumour necrosis factor (TNF)- α G -308A, interleukin (IL)-1β C 3954T, IL-6 G -174C and IL-10 G -1082A SNPs. Genomic DNA was isolated from remnant dried blood samples from the neonates. We tested the association between SNPs and ventilation characteristics using a stepwise multiple regression analysis model. Results. The carrier state of the TNF-α G -308A allele was associated with a 40-hour longer period of mechanical ventilation (p=0.004) and, on average, an additional 36 hours of oxygen supplementation (p=0.0008). The association was significant after its adjustment for perinatal risk factors for lung damage. Conclusions. The TNF-α G 308A genotype - which is associated with increased TNF-α levels - might influence the supplemental oxygen requirement of VLBW infants.

AB - Background. High levels of inflammatory cytokines lead to lung damage in premature newborns. We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the length of oxygen supplementation. Methods. We genotyped 123 very low birth weight (VLBW) infants for the tumour necrosis factor (TNF)- α G -308A, interleukin (IL)-1β C 3954T, IL-6 G -174C and IL-10 G -1082A SNPs. Genomic DNA was isolated from remnant dried blood samples from the neonates. We tested the association between SNPs and ventilation characteristics using a stepwise multiple regression analysis model. Results. The carrier state of the TNF-α G -308A allele was associated with a 40-hour longer period of mechanical ventilation (p=0.004) and, on average, an additional 36 hours of oxygen supplementation (p=0.0008). The association was significant after its adjustment for perinatal risk factors for lung damage. Conclusions. The TNF-α G 308A genotype - which is associated with increased TNF-α levels - might influence the supplemental oxygen requirement of VLBW infants.

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