The association of frailty with serum 25-hydroxyvitamin d and parathyroid hormone levels in older european men

Abdelouahid Tajar, David M. Lee, Stephen R. Pye, Matthew D L O'Connell, Rathi Ravindrarajah, Evelien Gielen, Steven Boonen, Dirk Vanderschueren, Neil Pendleton, Joseph D. Finn, G. Bártfai, Felipe F. Casanueva, Gianni Forti, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Michael E J Lean, Margus Punab, Frederick C W Wu & 1 others Terence W. O'Neill

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: the link between the vitamin D endocrine axis and frailty remains undefined, with few studies examining the joint effect of vitamin D and parathyroid hormone (PTH) levels. Our objective was to determine the association of frailty with serum 25-hydroxyvitamin D (25(OH)D) and PTH.Setting: cross-sectional analysis within the European Male Ageing Study (EMAS).Participants: a total of 1,504 community-dwelling men aged 60-79 years. Methods: frailty was classified using a frailty phenotype (FP) and frailty index (FI). The association of frailty with 25(OH)D and PTH was examined using multinomial logistic regression; individual FP criteria with 25(OH)D and PTH using binary logistic regression. Results were expressed as relative odds ratios (ROR) and 95% confidence intervals (CIs) for multinomial; odds ratios (OR) and 95% CIs for binary models. Results: using the FP, 5.0% of subjects were classified as frail and 36.6% as prefrail. Lower levels of 25(OH)D were associated with being prefrail (per 1 SD decrease: ROR = 1.45; 95% CI: 1.26-1.67) and frail (ROR = 1.89; 95% CI: 1.30-2.76), after adjusting for age, centre and health and lifestyle confounders (robust group = base category). Higher levels of PTH were associated with being frail after adjustment for confounders (per 1 SD increase: ROR = 1.24; 95% CI: 1.01-1.52). Comparable results were found using the FI. Among the five FP criteria only sarcopenia was not associated with 25(OH)D levels, while only weakness was associated with PTH. Conclusion: lower 25(OH)D and higher PTH levels were positively associated with frailty in older men. Prospective data would enable the temporal nature of this relationship to be explored further.

Original languageEnglish
Article numberafs162
Pages (from-to)352-359
Number of pages8
JournalAge and Ageing
Volume42
Issue number3
DOIs
Publication statusPublished - May 2013

Fingerprint

Parathyroid Hormone
Odds Ratio
Serum
Confidence Intervals
Phenotype
Vitamin D
Logistic Models
Sarcopenia
Independent Living
Life Style
Cross-Sectional Studies
Health

Keywords

  • Ageing
  • EMAS
  • Frailty
  • Male health
  • Older people
  • Parathyroid hormone
  • Population-based
  • Vitamin D

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Tajar, A., Lee, D. M., Pye, S. R., O'Connell, M. D. L., Ravindrarajah, R., Gielen, E., ... O'Neill, T. W. (2013). The association of frailty with serum 25-hydroxyvitamin d and parathyroid hormone levels in older european men. Age and Ageing, 42(3), 352-359. [afs162]. https://doi.org/10.1093/ageing/afs162

The association of frailty with serum 25-hydroxyvitamin d and parathyroid hormone levels in older european men. / Tajar, Abdelouahid; Lee, David M.; Pye, Stephen R.; O'Connell, Matthew D L; Ravindrarajah, Rathi; Gielen, Evelien; Boonen, Steven; Vanderschueren, Dirk; Pendleton, Neil; Finn, Joseph D.; Bártfai, G.; Casanueva, Felipe F.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Lean, Michael E J; Punab, Margus; Wu, Frederick C W; O'Neill, Terence W.

In: Age and Ageing, Vol. 42, No. 3, afs162, 05.2013, p. 352-359.

Research output: Contribution to journalArticle

Tajar, A, Lee, DM, Pye, SR, O'Connell, MDL, Ravindrarajah, R, Gielen, E, Boonen, S, Vanderschueren, D, Pendleton, N, Finn, JD, Bártfai, G, Casanueva, FF, Forti, G, Giwercman, A, Han, TS, Huhtaniemi, IT, Kula, K, Lean, MEJ, Punab, M, Wu, FCW & O'Neill, TW 2013, 'The association of frailty with serum 25-hydroxyvitamin d and parathyroid hormone levels in older european men', Age and Ageing, vol. 42, no. 3, afs162, pp. 352-359. https://doi.org/10.1093/ageing/afs162
Tajar A, Lee DM, Pye SR, O'Connell MDL, Ravindrarajah R, Gielen E et al. The association of frailty with serum 25-hydroxyvitamin d and parathyroid hormone levels in older european men. Age and Ageing. 2013 May;42(3):352-359. afs162. https://doi.org/10.1093/ageing/afs162
Tajar, Abdelouahid ; Lee, David M. ; Pye, Stephen R. ; O'Connell, Matthew D L ; Ravindrarajah, Rathi ; Gielen, Evelien ; Boonen, Steven ; Vanderschueren, Dirk ; Pendleton, Neil ; Finn, Joseph D. ; Bártfai, G. ; Casanueva, Felipe F. ; Forti, Gianni ; Giwercman, Aleksander ; Han, Thang S. ; Huhtaniemi, Ilpo T. ; Kula, Krzysztof ; Lean, Michael E J ; Punab, Margus ; Wu, Frederick C W ; O'Neill, Terence W. / The association of frailty with serum 25-hydroxyvitamin d and parathyroid hormone levels in older european men. In: Age and Ageing. 2013 ; Vol. 42, No. 3. pp. 352-359.
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abstract = "Background: the link between the vitamin D endocrine axis and frailty remains undefined, with few studies examining the joint effect of vitamin D and parathyroid hormone (PTH) levels. Our objective was to determine the association of frailty with serum 25-hydroxyvitamin D (25(OH)D) and PTH.Setting: cross-sectional analysis within the European Male Ageing Study (EMAS).Participants: a total of 1,504 community-dwelling men aged 60-79 years. Methods: frailty was classified using a frailty phenotype (FP) and frailty index (FI). The association of frailty with 25(OH)D and PTH was examined using multinomial logistic regression; individual FP criteria with 25(OH)D and PTH using binary logistic regression. Results were expressed as relative odds ratios (ROR) and 95{\%} confidence intervals (CIs) for multinomial; odds ratios (OR) and 95{\%} CIs for binary models. Results: using the FP, 5.0{\%} of subjects were classified as frail and 36.6{\%} as prefrail. Lower levels of 25(OH)D were associated with being prefrail (per 1 SD decrease: ROR = 1.45; 95{\%} CI: 1.26-1.67) and frail (ROR = 1.89; 95{\%} CI: 1.30-2.76), after adjusting for age, centre and health and lifestyle confounders (robust group = base category). Higher levels of PTH were associated with being frail after adjustment for confounders (per 1 SD increase: ROR = 1.24; 95{\%} CI: 1.01-1.52). Comparable results were found using the FI. Among the five FP criteria only sarcopenia was not associated with 25(OH)D levels, while only weakness was associated with PTH. Conclusion: lower 25(OH)D and higher PTH levels were positively associated with frailty in older men. Prospective data would enable the temporal nature of this relationship to be explored further.",
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AU - Pye, Stephen R.

AU - O'Connell, Matthew D L

AU - Ravindrarajah, Rathi

AU - Gielen, Evelien

AU - Boonen, Steven

AU - Vanderschueren, Dirk

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AU - Casanueva, Felipe F.

AU - Forti, Gianni

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AU - Han, Thang S.

AU - Huhtaniemi, Ilpo T.

AU - Kula, Krzysztof

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N2 - Background: the link between the vitamin D endocrine axis and frailty remains undefined, with few studies examining the joint effect of vitamin D and parathyroid hormone (PTH) levels. Our objective was to determine the association of frailty with serum 25-hydroxyvitamin D (25(OH)D) and PTH.Setting: cross-sectional analysis within the European Male Ageing Study (EMAS).Participants: a total of 1,504 community-dwelling men aged 60-79 years. Methods: frailty was classified using a frailty phenotype (FP) and frailty index (FI). The association of frailty with 25(OH)D and PTH was examined using multinomial logistic regression; individual FP criteria with 25(OH)D and PTH using binary logistic regression. Results were expressed as relative odds ratios (ROR) and 95% confidence intervals (CIs) for multinomial; odds ratios (OR) and 95% CIs for binary models. Results: using the FP, 5.0% of subjects were classified as frail and 36.6% as prefrail. Lower levels of 25(OH)D were associated with being prefrail (per 1 SD decrease: ROR = 1.45; 95% CI: 1.26-1.67) and frail (ROR = 1.89; 95% CI: 1.30-2.76), after adjusting for age, centre and health and lifestyle confounders (robust group = base category). Higher levels of PTH were associated with being frail after adjustment for confounders (per 1 SD increase: ROR = 1.24; 95% CI: 1.01-1.52). Comparable results were found using the FI. Among the five FP criteria only sarcopenia was not associated with 25(OH)D levels, while only weakness was associated with PTH. Conclusion: lower 25(OH)D and higher PTH levels were positively associated with frailty in older men. Prospective data would enable the temporal nature of this relationship to be explored further.

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