The assessment of neural injury following open heart surgery by physiological tremor analysis

Ádám Németh, László Hejjel, Zénó Ajtay, L. Kellényi, Andor Solymos, Imre Bártfai, N. Kovács, Zsófia Lenkey, Attila Cziráki, Sándor Szabados

Research output: Contribution to journalArticle

Abstract

Introduction: The appearance of post-operative cognitive dysfunction as a result of open heart surgery has been proven by several studies. Focal and/or sporadic neuron damage emerging in the central nervous system may not only appear as cognitive dysfunction, but might strongly influence features of physiological tremor. Material and methods: We investigated 110 patients (age: 34-73 years; 76 male, 34 female; 51 coronary artery bypass grafting (CABG), 25 valve replacement, 25 combined open heart surgery, 9 off-pump CABG) before surgery and after open-heart surgery on the 3rd to 5th post-operative day. The assessment of the physiological tremor analysis was performed with our newly developed equipment based on the Analog Devices ADXL 320 JPC integrated accelerometer chip. Recordings were stored on a PC and spectral analysis was performed by fast Fourier transformation (FFT). We compared power integrals in the 1-4 Hz, 4-8 Hz and 8-12 Hz frequency ranges and these were statistically assessed by the Wilcoxon rank correlation test. Results: We found significant changes in the power spectrum of physiological tremor. The spectrum in the 8-12 Hz range (neuronal oscillation) decreased and a shift was recognised to the lower spectrum (p <0.01). The magnitude of the shift was not significantly higher for females than for males (p <0.157). We found no significant difference between the shift and the cross-clamp or perfusion time (p <0.6450). Conclusions: The assessment of physiological tremor by means of our novel, feasible method may provide a deeper insight into the mechanism of central nervous system damage associated with open heart surgery.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalArchives of Medical Science
Volume9
Issue number1
DOIs
Publication statusPublished - Feb 2013

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Tremor
Thoracic Surgery
Wounds and Injuries
Coronary Artery Bypass
Central Nervous System
Off-Pump Coronary Artery Bypass
Equipment and Supplies
Nonparametric Statistics
Perfusion
Neurons
Cognitive Dysfunction

Keywords

  • Cognitive dysfunction
  • Open heart surgery
  • Physiological tremor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Németh, Á., Hejjel, L., Ajtay, Z., Kellényi, L., Solymos, A., Bártfai, I., ... Szabados, S. (2013). The assessment of neural injury following open heart surgery by physiological tremor analysis. Archives of Medical Science, 9(1), 40-46. https://doi.org/10.5114/aoms.2013.33347

The assessment of neural injury following open heart surgery by physiological tremor analysis. / Németh, Ádám; Hejjel, László; Ajtay, Zénó; Kellényi, L.; Solymos, Andor; Bártfai, Imre; Kovács, N.; Lenkey, Zsófia; Cziráki, Attila; Szabados, Sándor.

In: Archives of Medical Science, Vol. 9, No. 1, 02.2013, p. 40-46.

Research output: Contribution to journalArticle

Németh, Á, Hejjel, L, Ajtay, Z, Kellényi, L, Solymos, A, Bártfai, I, Kovács, N, Lenkey, Z, Cziráki, A & Szabados, S 2013, 'The assessment of neural injury following open heart surgery by physiological tremor analysis', Archives of Medical Science, vol. 9, no. 1, pp. 40-46. https://doi.org/10.5114/aoms.2013.33347
Németh, Ádám ; Hejjel, László ; Ajtay, Zénó ; Kellényi, L. ; Solymos, Andor ; Bártfai, Imre ; Kovács, N. ; Lenkey, Zsófia ; Cziráki, Attila ; Szabados, Sándor. / The assessment of neural injury following open heart surgery by physiological tremor analysis. In: Archives of Medical Science. 2013 ; Vol. 9, No. 1. pp. 40-46.
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AU - Solymos, Andor

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