The application of immunofluorescent antibody method in research of human brain edema

A. Fazekas, S. Komoly

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The direct and indirect immunofluorescent methods were used to demonstrate the serum proteins in vasogenic brain edema on paraffin embedded formalin fixed human brains with carcinoma metastases. Applying these techniques extravasated albumin was detected within the tumor and in the surrounding neuropil. In the remote part of the peritumorous area the cytoplasma of neurons and astrocytes were stained specifically. The specific immunostaining clearly demonstrates the plasma origin of proteins in human peritumorous edema similarly to the experimental vasogenic brain edema. The immunofluorescent technique seems to be very useful to investigate the human brain edema on necropsy material as well.

Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalNeuroscience Letters
Volume17
Issue number3
DOIs
Publication statusPublished - May 1 1980

Fingerprint

Brain Edema
Antibodies
Blood Proteins
Research
Neuropil
Astrocytes
Paraffin
Formaldehyde
Albumins
Edema
Neoplasm Metastasis
Carcinoma
Neurons
Brain
Neoplasms

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The application of immunofluorescent antibody method in research of human brain edema. / Fazekas, A.; Komoly, S.

In: Neuroscience Letters, Vol. 17, No. 3, 01.05.1980, p. 323-327.

Research output: Contribution to journalArticle

@article{3639bcca67c741059798e7350463b12d,
title = "The application of immunofluorescent antibody method in research of human brain edema",
abstract = "The direct and indirect immunofluorescent methods were used to demonstrate the serum proteins in vasogenic brain edema on paraffin embedded formalin fixed human brains with carcinoma metastases. Applying these techniques extravasated albumin was detected within the tumor and in the surrounding neuropil. In the remote part of the peritumorous area the cytoplasma of neurons and astrocytes were stained specifically. The specific immunostaining clearly demonstrates the plasma origin of proteins in human peritumorous edema similarly to the experimental vasogenic brain edema. The immunofluorescent technique seems to be very useful to investigate the human brain edema on necropsy material as well.",
author = "A. Fazekas and S. Komoly",
year = "1980",
month = "5",
day = "1",
doi = "10.1016/0304-3940(80)90044-0",
language = "English",
volume = "17",
pages = "323--327",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - The application of immunofluorescent antibody method in research of human brain edema

AU - Fazekas, A.

AU - Komoly, S.

PY - 1980/5/1

Y1 - 1980/5/1

N2 - The direct and indirect immunofluorescent methods were used to demonstrate the serum proteins in vasogenic brain edema on paraffin embedded formalin fixed human brains with carcinoma metastases. Applying these techniques extravasated albumin was detected within the tumor and in the surrounding neuropil. In the remote part of the peritumorous area the cytoplasma of neurons and astrocytes were stained specifically. The specific immunostaining clearly demonstrates the plasma origin of proteins in human peritumorous edema similarly to the experimental vasogenic brain edema. The immunofluorescent technique seems to be very useful to investigate the human brain edema on necropsy material as well.

AB - The direct and indirect immunofluorescent methods were used to demonstrate the serum proteins in vasogenic brain edema on paraffin embedded formalin fixed human brains with carcinoma metastases. Applying these techniques extravasated albumin was detected within the tumor and in the surrounding neuropil. In the remote part of the peritumorous area the cytoplasma of neurons and astrocytes were stained specifically. The specific immunostaining clearly demonstrates the plasma origin of proteins in human peritumorous edema similarly to the experimental vasogenic brain edema. The immunofluorescent technique seems to be very useful to investigate the human brain edema on necropsy material as well.

UR - http://www.scopus.com/inward/record.url?scp=0019307282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019307282&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(80)90044-0

DO - 10.1016/0304-3940(80)90044-0

M3 - Article

VL - 17

SP - 323

EP - 327

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -