The application of canonical analysis to the evaluation of the influence of changes in components of standard direct compression tablet formulations

Fridrun Podczeck, Gabriele Merkel, Piroska Révész

Research output: Contribution to journalArticle

15 Citations (Scopus)


Different types of microcrystalline and microfine celluloses are often used in direct tabletting mixtures. An evaluation has been undertaken of the connection between the pharmaceutical behaviour of a range of the cellulose products and the powder and tablet properties of the tabletting mixtures, using the multivariate statistical technique of canonical analysis. The cellulose properties were reflected in the behaviour of the tabletting mixtures, in particular the bulk volume, the particle size range, the formation energy (force-displacement-curves, E2) and the elastic recovery energy (E3). The approach demonstrated that an exchange of the cellulose product in direct tabletting mixtures is only possible in special cases.

Original languageEnglish
Pages (from-to)15-28
Number of pages14
JournalInternational Journal of Pharmaceutics
Issue number1-3
Publication statusPublished - Aug 15 1993



  • Basic mixture
  • Canonical analysis
  • Cellulose powder
  • Direct compression
  • Multivariate statistical analysis
  • Pharmaceutical technology

ASJC Scopus subject areas

  • Pharmaceutical Science

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