The antidysrhythmic aminosteroid, ORG 6001, reduces the ST-segment elevation produced by coronary occlusion in the dog

R. J. Marshall, J. R. Parratt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greately reduced by the prior administration of the antidysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.

Original languageEnglish
Pages (from-to)315-317
Number of pages3
JournalBritish Journal of Pharmacology
Volume61
Issue number2
Publication statusPublished - 1977

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Coronary Occlusion
Myocardial Ischemia
Coronary Vessels
Thorax
Dogs

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greately reduced by the prior administration of the antidysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.",
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