The anticonvulsive effect of non-NMDA antagonist GYKI 52466 on 3-aminopyridine-induced primary and secondary cortical ictal activity in rat

Barbara Barna, M. Szente, A. Szász

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of GYKI 52466, a selective, non-competitive antagonist of the AMPA glutamate receptor subtype was investigated on the development, expression and propagation of 3-aminopyridine-induced cortical ictal activity, both in the primary and secondary focus. In one group of animals GYKI 52466 was administered intraperitoneally, 20 minutes prior to the local application of the convulsant the surface of the cortex of anaesthetized rats. Control animals were injected by physiological solution. Different parameters of electrographic ictal discharges were measured under the influence of the antagonist and compared to control values. The results demonstrate that GYKI 52466 exerts anticonvulsive effects on both the induction and the expression of primary and secondary electrical ictal activity, by delaying the onset of the first ictal period, shortening the duration of ictal activity and decreasing the amplitudes of epileptiform discharges. However, the seizure propagation was not influenced significantly. It is suggested that the initiation, maintenance and the propagation of spontaneous seizures may be controlled by separate mechanisms and that changes can occur in one of the procedures without parallel changes in others. The observations of the present study extend those reported previously by others namely that activation of non-NMDA receptors is significantly involved in the initiation and maintenance of cortical epileptiform activity.

Original languageEnglish
Pages (from-to)257-267
Number of pages11
JournalActa Biologica Hungarica
Volume50
Issue number1-3
Publication statusPublished - 1999

Fingerprint

stroke
Rats
antagonists
Stroke
animal
rats
Animals
Convulsants
seizures
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Glutamate Receptors
Seizures
Discharge (fluid mechanics)
Maintenance
Excitatory Amino Acid Antagonists
Chemical activation
AMPA Receptors
shortenings
animals
cortex

Keywords

  • AMPA receptors
  • Antiepileptic
  • Experimental epilepsy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

The anticonvulsive effect of non-NMDA antagonist GYKI 52466 on 3-aminopyridine-induced primary and secondary cortical ictal activity in rat. / Barna, Barbara; Szente, M.; Szász, A.

In: Acta Biologica Hungarica, Vol. 50, No. 1-3, 1999, p. 257-267.

Research output: Contribution to journalArticle

@article{c70f6b28b6d24388bb1f423ec2bcdea2,
title = "The anticonvulsive effect of non-NMDA antagonist GYKI 52466 on 3-aminopyridine-induced primary and secondary cortical ictal activity in rat",
abstract = "The effect of GYKI 52466, a selective, non-competitive antagonist of the AMPA glutamate receptor subtype was investigated on the development, expression and propagation of 3-aminopyridine-induced cortical ictal activity, both in the primary and secondary focus. In one group of animals GYKI 52466 was administered intraperitoneally, 20 minutes prior to the local application of the convulsant the surface of the cortex of anaesthetized rats. Control animals were injected by physiological solution. Different parameters of electrographic ictal discharges were measured under the influence of the antagonist and compared to control values. The results demonstrate that GYKI 52466 exerts anticonvulsive effects on both the induction and the expression of primary and secondary electrical ictal activity, by delaying the onset of the first ictal period, shortening the duration of ictal activity and decreasing the amplitudes of epileptiform discharges. However, the seizure propagation was not influenced significantly. It is suggested that the initiation, maintenance and the propagation of spontaneous seizures may be controlled by separate mechanisms and that changes can occur in one of the procedures without parallel changes in others. The observations of the present study extend those reported previously by others namely that activation of non-NMDA receptors is significantly involved in the initiation and maintenance of cortical epileptiform activity.",
keywords = "AMPA receptors, Antiepileptic, Experimental epilepsy",
author = "Barbara Barna and M. Szente and A. Sz{\'a}sz",
year = "1999",
language = "English",
volume = "50",
pages = "257--267",
journal = "Acta Biologica Hungarica",
issn = "0236-5383",
publisher = "Akademiai Kiado",
number = "1-3",

}

TY - JOUR

T1 - The anticonvulsive effect of non-NMDA antagonist GYKI 52466 on 3-aminopyridine-induced primary and secondary cortical ictal activity in rat

AU - Barna, Barbara

AU - Szente, M.

AU - Szász, A.

PY - 1999

Y1 - 1999

N2 - The effect of GYKI 52466, a selective, non-competitive antagonist of the AMPA glutamate receptor subtype was investigated on the development, expression and propagation of 3-aminopyridine-induced cortical ictal activity, both in the primary and secondary focus. In one group of animals GYKI 52466 was administered intraperitoneally, 20 minutes prior to the local application of the convulsant the surface of the cortex of anaesthetized rats. Control animals were injected by physiological solution. Different parameters of electrographic ictal discharges were measured under the influence of the antagonist and compared to control values. The results demonstrate that GYKI 52466 exerts anticonvulsive effects on both the induction and the expression of primary and secondary electrical ictal activity, by delaying the onset of the first ictal period, shortening the duration of ictal activity and decreasing the amplitudes of epileptiform discharges. However, the seizure propagation was not influenced significantly. It is suggested that the initiation, maintenance and the propagation of spontaneous seizures may be controlled by separate mechanisms and that changes can occur in one of the procedures without parallel changes in others. The observations of the present study extend those reported previously by others namely that activation of non-NMDA receptors is significantly involved in the initiation and maintenance of cortical epileptiform activity.

AB - The effect of GYKI 52466, a selective, non-competitive antagonist of the AMPA glutamate receptor subtype was investigated on the development, expression and propagation of 3-aminopyridine-induced cortical ictal activity, both in the primary and secondary focus. In one group of animals GYKI 52466 was administered intraperitoneally, 20 minutes prior to the local application of the convulsant the surface of the cortex of anaesthetized rats. Control animals were injected by physiological solution. Different parameters of electrographic ictal discharges were measured under the influence of the antagonist and compared to control values. The results demonstrate that GYKI 52466 exerts anticonvulsive effects on both the induction and the expression of primary and secondary electrical ictal activity, by delaying the onset of the first ictal period, shortening the duration of ictal activity and decreasing the amplitudes of epileptiform discharges. However, the seizure propagation was not influenced significantly. It is suggested that the initiation, maintenance and the propagation of spontaneous seizures may be controlled by separate mechanisms and that changes can occur in one of the procedures without parallel changes in others. The observations of the present study extend those reported previously by others namely that activation of non-NMDA receptors is significantly involved in the initiation and maintenance of cortical epileptiform activity.

KW - AMPA receptors

KW - Antiepileptic

KW - Experimental epilepsy

UR - http://www.scopus.com/inward/record.url?scp=0032745372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032745372&partnerID=8YFLogxK

M3 - Article

C2 - 10574445

AN - SCOPUS:0032745372

VL - 50

SP - 257

EP - 267

JO - Acta Biologica Hungarica

JF - Acta Biologica Hungarica

SN - 0236-5383

IS - 1-3

ER -