The alteration of Irisin-Brain-derived neurotrophic factor axis parallels severity of distress disorder in bronchial asthma patients

Magdolna E. Szilasi, Krisztian Pak, Laszlo Kardos, Viktoria E. Varga, I. Seres, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Gabor Tajti, C. Papp, R. Gesztelyi, Judit Zsuga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma. The irisin-brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of distress disorder. Thus, the aim of the present study was to quantify the serum irisin and BDNF concentrations in order to investigate the possible link between the irisin/BDNF axis and distress disorder in an asthma patient cohort. Data of 167 therapy-controlled asthma patients were analyzed. Demographic, anthropometric, and anamnestic data were collected, routine laboratory parameters supplemented with serum irisin and BDNF levels were determined, pulmonary function test was performed using whole-body plethysmography, and quality of life was quantified by means of the St. George's Respiratory Questionnaire (SGRQ). Correlation analysis as well as simple and multiple linear regression were used to assess the relationship between the irisin level and the Impacts score of SGRQ, which latter is indicative of the presence and severity of distress disorder. We have found a significant, positive linear relationship between the Impacts score and the reciprocal of irisin level. This association was stronger in patients whose BDNF level was higher, and it was weaker (and statistically non-significant) in patients whose BDNF level was lower. Our results indicate that higher serum irisin level together with higher serum BDNF level are associated with milder (or no) distress disorder. This finding suggests that alteration of the irisin/BDNF axis influences the presence and severity of distress disorder in asthma patients.

Original languageEnglish
Article number653
JournalFrontiers in Neuroscience
Volume11
Issue numberNOV
DOIs
Publication statusPublished - Nov 23 2017

Fingerprint

Brain-Derived Neurotrophic Factor
Asthma
Serum
Whole Body Plethysmography
Respiratory Function Tests
Major Depressive Disorder
Anxiety Disorders
Linear Models
Quality of Life
Demography
Morbidity

Keywords

  • BDNF
  • Bronchial asthma
  • Distress disorder
  • Irisin
  • SGRQ
  • Whole-body plethysmography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The alteration of Irisin-Brain-derived neurotrophic factor axis parallels severity of distress disorder in bronchial asthma patients. / Szilasi, Magdolna E.; Pak, Krisztian; Kardos, Laszlo; Varga, Viktoria E.; Seres, I.; Mikaczo, Angela; Fodor, Andrea; Szilasi, Maria; Tajti, Gabor; Papp, C.; Gesztelyi, R.; Zsuga, Judit.

In: Frontiers in Neuroscience, Vol. 11, No. NOV, 653, 23.11.2017.

Research output: Contribution to journalArticle

Szilasi, Magdolna E. ; Pak, Krisztian ; Kardos, Laszlo ; Varga, Viktoria E. ; Seres, I. ; Mikaczo, Angela ; Fodor, Andrea ; Szilasi, Maria ; Tajti, Gabor ; Papp, C. ; Gesztelyi, R. ; Zsuga, Judit. / The alteration of Irisin-Brain-derived neurotrophic factor axis parallels severity of distress disorder in bronchial asthma patients. In: Frontiers in Neuroscience. 2017 ; Vol. 11, No. NOV.
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AU - Szilasi, Magdolna E.

AU - Pak, Krisztian

AU - Kardos, Laszlo

AU - Varga, Viktoria E.

AU - Seres, I.

AU - Mikaczo, Angela

AU - Fodor, Andrea

AU - Szilasi, Maria

AU - Tajti, Gabor

AU - Papp, C.

AU - Gesztelyi, R.

AU - Zsuga, Judit

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AB - Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma. The irisin-brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of distress disorder. Thus, the aim of the present study was to quantify the serum irisin and BDNF concentrations in order to investigate the possible link between the irisin/BDNF axis and distress disorder in an asthma patient cohort. Data of 167 therapy-controlled asthma patients were analyzed. Demographic, anthropometric, and anamnestic data were collected, routine laboratory parameters supplemented with serum irisin and BDNF levels were determined, pulmonary function test was performed using whole-body plethysmography, and quality of life was quantified by means of the St. George's Respiratory Questionnaire (SGRQ). Correlation analysis as well as simple and multiple linear regression were used to assess the relationship between the irisin level and the Impacts score of SGRQ, which latter is indicative of the presence and severity of distress disorder. We have found a significant, positive linear relationship between the Impacts score and the reciprocal of irisin level. This association was stronger in patients whose BDNF level was higher, and it was weaker (and statistically non-significant) in patients whose BDNF level was lower. Our results indicate that higher serum irisin level together with higher serum BDNF level are associated with milder (or no) distress disorder. This finding suggests that alteration of the irisin/BDNF axis influences the presence and severity of distress disorder in asthma patients.

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KW - Whole-body plethysmography

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