The acute effects of alcohol on cerebral hemodynamic changes induced by the head-up tilt test in healthy subjects

Sandor Viski, Miklos Orosz, Katalin Reka Czuriga-Kovacs, M. Magyar, L. Csiba, L. Oláh

Research output: Contribution to journalArticle

4 Citations (Scopus)


Background Alcohol is a known triggering factor for orthostatic dysfunction, increasing the risk of neurally-mediated syncope. Since orthostatic tolerance may be affected by both systemic and cerebral hemodynamic changes, our aim was to investigate the acute effects of alcohol on cerebral vasoreactivity measured during the head-up tilt (HUT) test in 20 healthy subjects. Methods Mean arterial blood pressure (mBP), heart rate, and flow parameters in both middle cerebral arteries (MCAs) were continuously recorded in the supine and during a 10-minute HUT positions before and after alcohol intake. Results The HUT test resulted in a more prominent decline of adjusted mBP at the level of MCAs (mBPMCA) and a significantly larger decrease of MCA mean flow velocities (MFVMCA) in the post-alcohol period than before alcohol intake. During the HUT phase, the relative decrease in MFVMCA was significantly smaller than the reduction in mBPMCA before drinking alcohol, while these changes were similar after alcohol ingestion. The cerebrovascular resistance index (CVRi) decreased during the HUT phase in the control period, however, it increased after alcohol intake. Conclusion The similar decrease in mBPMCA and MFVMCA during orthostatic stress after alcohol ingestion together with the increased CVRi indicated the impairment of the compensatory vasodilation of cerebral resistance vessels, i.e. impaired cerebral autoregulation. These findings suggest that alcohol may contribute to impaired orthostatic tolerance not only by a hypotensive response but also by the alteration of cerebral blood flow regulation.

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalJournal of the Neurological Sciences
Publication statusPublished - Sep 15 2016


  • Alcohol
  • Baroreceptor reflex
  • Cerebral autoregulation
  • Cerebral blood flow
  • Head-up tilt test
  • Orthostatic stress
  • Transcranial doppler

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'The acute effects of alcohol on cerebral hemodynamic changes induced by the head-up tilt test in healthy subjects'. Together they form a unique fingerprint.

  • Cite this