The action of pituitary adenylate cyclase activating polypeptide (PACAP) on passive avoidance learning. the role of transmitters

G. Telegdy, Katalin Kokavszky

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

In the present study, the action of PACAP 38 on one-way passive avoidance learning was investigated. PACAP-38 was administered into the lateral brain ventricle and the latency of the passive avoidance response was measured 24 h later. In order to study the possible roles of various neurotransmitters in mediating the action of PACAP on the consolidation of passive avoidance learning, the animals were pre-treated with receptor blockers in doses that per se proved to be ineffective. PACAP facilitated the learning, the consolidation of learning and the retrieval of the passive avoidance response. The following receptor blockers attenuated the action of PACAP on this consolidation: haloperidol, phenoxybenzamine, propranolol and methysergide. An antagonist of PACAP 38, PACAP 6-38, and also nitro-L-arginine (the latter blocks the enzyme nitric oxide synthase) thereby inhibiting the formation of NO from L-arginine, completely blocked the action of PACAP 38 on consolidation. The following receptor blockers were ineffective: naloxone, bicuculline and atropine. The presented data suggest that PACAP 38 is able to improve the learning and memory processes in a passive avoidance paradigm. In this action, the PACAP 38 receptor and NO are important mediators. Dopaminergic, alpha- and beta-adrenergic mediation and serotonin receptors modified the action of PACAP 38, but they are probably not of great importance.

Original languageEnglish
Pages (from-to)194-199
Number of pages6
JournalBrain Research
Volume874
Issue number2
Publication statusPublished - Aug 25 2000

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Avoidance Learning
Pituitary Adenylate Cyclase-Activating Polypeptide
Learning
Arginine
Pituitary Adenylate Cyclase-Activating Polypeptide Receptors
Methysergide
Phenoxybenzamine
Bicuculline
Lateral Ventricles
Serotonin Receptors
Receptors, Adrenergic, beta
Haloperidol
Naloxone
Atropine
Propranolol
Nitric Oxide Synthase
Neurotransmitter Agents

Keywords

  • Neurotransmitter
  • PACAP
  • Passive avoidance learning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

The action of pituitary adenylate cyclase activating polypeptide (PACAP) on passive avoidance learning. the role of transmitters. / Telegdy, G.; Kokavszky, Katalin.

In: Brain Research, Vol. 874, No. 2, 25.08.2000, p. 194-199.

Research output: Contribution to journalArticle

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