The action of peptides and proteases on the arachidonate cascade of human and rat platelets.

A. Gecse, Z. Mezei, G. Telegdy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The arachidonate cascade of human or rat platelets were found to be modified by peptides (bradykinin, angiotensin I, angiotensin II, Asp1-Val5-angiotensin II-amide, somatostatin) and proteases (trypsin, kallikrein). The lipoxygenase pathway was not altered by angiotensin I, angiotensin II, trypsin and kallikrein, while the synthesis some of the cyclooxygenase products was selectively changed by these substances. Bradykinin and somatostatin resulted in an attenuated formation of 12-HPETE and 12-HETE - U shape dose response curve, at the same time the synthesis of cyclooxygenase metabolites was increased - bell shape dose response curve. Asp1-Val5-angiotensin II-amide increased the synthesis of lipoxygenase products and diminished the formation of TxB2. At the same time this peptide selectively induced the enzymatic release of PGD2 from platelets. These peptides and proteolytic enzymes might have physiologic significance in the "Ying-Yang" balance in one hand between lipoxygenase and cyclooxygenase metabolites and on the other between the proaggregatory and antiaggregatory substances released from platelets.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume198 Pt B
Publication statusPublished - 1986

Fingerprint

Lipoxygenase
Prostaglandin-Endoperoxide Synthases
Platelets
Rats
Angiotensin I
Kallikreins
Peptide Hydrolases
Blood Platelets
Bradykinin
Metabolites
Somatostatin
Angiotensin II
Trypsin
Peptides
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Prostaglandin D2
Hand
angiotensin II amide

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The action of peptides and proteases on the arachidonate cascade of human and rat platelets. / Gecse, A.; Mezei, Z.; Telegdy, G.

In: Advances in Experimental Medicine and Biology, Vol. 198 Pt B, 1986, p. 121-128.

Research output: Contribution to journalArticle

@article{9d080fafa5da4cce92dc30cdb2162b4b,
title = "The action of peptides and proteases on the arachidonate cascade of human and rat platelets.",
abstract = "The arachidonate cascade of human or rat platelets were found to be modified by peptides (bradykinin, angiotensin I, angiotensin II, Asp1-Val5-angiotensin II-amide, somatostatin) and proteases (trypsin, kallikrein). The lipoxygenase pathway was not altered by angiotensin I, angiotensin II, trypsin and kallikrein, while the synthesis some of the cyclooxygenase products was selectively changed by these substances. Bradykinin and somatostatin resulted in an attenuated formation of 12-HPETE and 12-HETE - U shape dose response curve, at the same time the synthesis of cyclooxygenase metabolites was increased - bell shape dose response curve. Asp1-Val5-angiotensin II-amide increased the synthesis of lipoxygenase products and diminished the formation of TxB2. At the same time this peptide selectively induced the enzymatic release of PGD2 from platelets. These peptides and proteolytic enzymes might have physiologic significance in the {"}Ying-Yang{"} balance in one hand between lipoxygenase and cyclooxygenase metabolites and on the other between the proaggregatory and antiaggregatory substances released from platelets.",
author = "A. Gecse and Z. Mezei and G. Telegdy",
year = "1986",
language = "English",
volume = "198 Pt B",
pages = "121--128",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer New York",

}

TY - JOUR

T1 - The action of peptides and proteases on the arachidonate cascade of human and rat platelets.

AU - Gecse, A.

AU - Mezei, Z.

AU - Telegdy, G.

PY - 1986

Y1 - 1986

N2 - The arachidonate cascade of human or rat platelets were found to be modified by peptides (bradykinin, angiotensin I, angiotensin II, Asp1-Val5-angiotensin II-amide, somatostatin) and proteases (trypsin, kallikrein). The lipoxygenase pathway was not altered by angiotensin I, angiotensin II, trypsin and kallikrein, while the synthesis some of the cyclooxygenase products was selectively changed by these substances. Bradykinin and somatostatin resulted in an attenuated formation of 12-HPETE and 12-HETE - U shape dose response curve, at the same time the synthesis of cyclooxygenase metabolites was increased - bell shape dose response curve. Asp1-Val5-angiotensin II-amide increased the synthesis of lipoxygenase products and diminished the formation of TxB2. At the same time this peptide selectively induced the enzymatic release of PGD2 from platelets. These peptides and proteolytic enzymes might have physiologic significance in the "Ying-Yang" balance in one hand between lipoxygenase and cyclooxygenase metabolites and on the other between the proaggregatory and antiaggregatory substances released from platelets.

AB - The arachidonate cascade of human or rat platelets were found to be modified by peptides (bradykinin, angiotensin I, angiotensin II, Asp1-Val5-angiotensin II-amide, somatostatin) and proteases (trypsin, kallikrein). The lipoxygenase pathway was not altered by angiotensin I, angiotensin II, trypsin and kallikrein, while the synthesis some of the cyclooxygenase products was selectively changed by these substances. Bradykinin and somatostatin resulted in an attenuated formation of 12-HPETE and 12-HETE - U shape dose response curve, at the same time the synthesis of cyclooxygenase metabolites was increased - bell shape dose response curve. Asp1-Val5-angiotensin II-amide increased the synthesis of lipoxygenase products and diminished the formation of TxB2. At the same time this peptide selectively induced the enzymatic release of PGD2 from platelets. These peptides and proteolytic enzymes might have physiologic significance in the "Ying-Yang" balance in one hand between lipoxygenase and cyclooxygenase metabolites and on the other between the proaggregatory and antiaggregatory substances released from platelets.

UR - http://www.scopus.com/inward/record.url?scp=0022960671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022960671&partnerID=8YFLogxK

M3 - Article

C2 - 2880482

AN - SCOPUS:0022960671

VL - 198 Pt B

SP - 121

EP - 128

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -