The action of orexin B on passive avoidance learning. Involvement of neurotransmitters

Miklós Palotai, G. Telegdy, Alphonsus Ekwerike, M. Jászberényi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The extensive projection of orexigenic neurons and the diffuse expression of orexin receptors suggest that endogenous orexins are involved in several physiological functions of the central nervous system, including learning and memory. Our previous study demonstrated that orexin A improves learning, consolidation and retrieval processes, which involves α- and β-adrenergic, cholinergic, dopaminergic, GABA-A-ergic, opiate and nitrergic neurotransmissions. However, we have little evidence about the action of orexin B on memory processes and the underlying neuromodulation. Therefore, the aim of the present study was to investigate the action of orexin B on passive avoidance learning and the involvement of neurotransmitters in this action in rats. Accordingly, rats were pretreated with the selective orexin 2 receptor (OX2R) antagonist, EMPA; the γ-aminobutyric acid subunit A (GABA-A) receptor antagonist, the bicuculline; a D2, D3, D4 dopamine receptor antagonist, haloperidol; the nonselective opioid receptor antagonist, naloxone; the non-specific nitric oxide synthase (NOS) inhibitor, nitro-. l-arginine; the nonselective α-adrenergic receptor antagonist, phenoxybenzamine and the β-adrenergic receptor antagonist, propranolol. Our results demonstrate that orexin B can improve learning, consolidation of memory and retrieval. EMPA reversed completely the action of orexin B on memory consolidation. Bicuculline blocked fully; naloxone, nitro-. l-arginine, phenoxybenzamine and propranolol attenuated the orexin B-induced memory consolidation, whereas haloperidol was ineffective. These data suggest that orexin B improves memory functions through OX2R and GABA-ergic, opiate, nitrergic, α- and β-adrenergic neurotransmissions are also involved in this action.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalBehavioural Brain Research
Volume272
DOIs
Publication statusPublished - Oct 1 2014

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Avoidance Learning
Neurotransmitter Agents
Opiate Alkaloids
Orexin Receptors
Phenoxybenzamine
Adrenergic Antagonists
Bicuculline
Learning
Haloperidol
Naloxone
Propranolol
Synaptic Transmission
Adrenergic Agents
gamma-Aminobutyric Acid
Arginine
Aminobutyrates
GABA-A Receptor Antagonists
Narcotic Antagonists
Dopamine Antagonists
Orexins

Keywords

  • Neurotransmitter
  • Orexin B
  • Passive avoidance learning

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Medicine(all)

Cite this

The action of orexin B on passive avoidance learning. Involvement of neurotransmitters. / Palotai, Miklós; Telegdy, G.; Ekwerike, Alphonsus; Jászberényi, M.

In: Behavioural Brain Research, Vol. 272, 01.10.2014, p. 1-7.

Research output: Contribution to journalArticle

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