The action of neuropeptide AF on passive avoidance learning. Involvement of neurotransmitters

Miklós Palotai, G. Telegdy, Zsolt Bagosi, M. Jászberényi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neuropeptide AF (NPAF) is an amidated octadecapeptide, which is member of the RFamide peptide family. NPAF is encoded by the farp-1 gene and acts through the G protein coupled NPFF-1 and NPFF-2 receptors. NPAF is involved in several physiological functions of the central nervous system, however we have little evidence about the involvement of NPAF in learning and memory. Therefore, the aim of the present study was to investigate the action of NPAF on consolidation of memory in a passive avoidance learning paradigm in mice. We have also investigated the underlying neurotransmissions and the action of NPAF on β-amyloid-induced memory impairment. Accordingly, mice were pretreated with a nonselective muscarinic acetylcholine receptor antagonist, atropine, a non-selective 5-HT2 serotonergic receptor antagonist, cyproheptadine, a mixed 5-HT1/5-HT2 serotonergic receptor antagonist, methysergide, a D2, D3, D4 dopamine receptor antagonist, haloperidol, a non-selective opioid receptor antagonist, naloxone, a nitric oxide synthase inhibitor, nitro-l-arginine, a α1-adrenergic receptor antagonist, prazosin, a nonselective β-adrenergic receptor antagonist, propranolol or β-amyloid 25-35 in combination with NPAF administration. Our results demonstrate for the first time that NPAF improves the consolidation of passive avoidance learning. This effect is mediated through muscarinic cholinergic, 5HT1- and 5HT2-serotoninergic, dopaminergic, nitrergic and α- and β-adrenergic neurotransmissions, but not by opioid transmission, since atropine, cyproheptadine, methysergide, haloperidol, nitro-l-arginine, prazosin and propranolol reversed the action of NPAF, whereas naloxone was ineffective. The present study also shows that NPAF reverses the β-amyloid 25-35-induced memory impairment.

Original languageEnglish
Pages (from-to)34-41
Number of pages8
JournalNeurobiology of Learning and Memory
Volume127
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Avoidance Learning
Neurotransmitter Agents
Amyloid
Cyproheptadine
Methysergide
Adrenergic Antagonists
Prazosin
Haloperidol
Naloxone
Atropine
Propranolol
Synaptic Transmission
Cholinergic Agents
Arginine
A18Famide
Narcotic Antagonists
Dopamine Antagonists
Cholinergic Antagonists
Muscarinic Receptors
GTP-Binding Proteins

Keywords

  • Neuropeptide AF
  • Neurotransmitter
  • Passive avoidance learning
  • β-amyloid

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

The action of neuropeptide AF on passive avoidance learning. Involvement of neurotransmitters. / Palotai, Miklós; Telegdy, G.; Bagosi, Zsolt; Jászberényi, M.

In: Neurobiology of Learning and Memory, Vol. 127, 01.01.2016, p. 34-41.

Research output: Contribution to journalArticle

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