The action of isatin (2,3-dioxoindole) an endogenous indole on brain natriuretic and C-type natriuretic peptide-induced facilitation of memory consolidation in passive-avoidance learning in rats

G. Telegdy, A. Adamik, V. Glover

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Isatin is an endogenous indole which has been shown to counteract some of the effects of atrial natriuretic peptide (ANP) both in vitro and in vivo. The present study was designed to determine whether it could antagonise in vivo effects of the related peptides brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). The model used was consolidation of memory in a one-trial step-through passive-avoidance paradigm in the rat. Previous studies have shown that all three peptides (1 μg intracerebroventricular) can consolidate such learning and increase latency to entry a dark box. Isatin was given intraperitoneally at doses of 5, 10 and 50 mg/kg before the peptide, or a saline control. Both BNP and CNP significantly increased the latency of entry. Isatin alone had no effect. Isatin reduced the effect of both BNP and CNP; this was significant for its effect on BNP at 50 mg/kg and on CNP at both 10 and 50 mg/kg. These results show that isatin can inhibit behavioural effects of BNP and CNP as well as ANP. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalBrain Research Bulletin
Volume53
Issue number3
DOIs
Publication statusPublished - Dec 16 2000

Keywords

  • BNP
  • CNP
  • Isatin
  • Passive-avoidance learning

ASJC Scopus subject areas

  • Neuroscience(all)

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