The 8.1 ancestral MHC haplotype is strongly associated with colorectal cancer risk

Éva Katalin Tóth, Judit Kocsis, Balázs Madaras, Adrienn Bíró, Zsuzsa Pocsai, George Fust, Bernadett Blaskó, István Karádi, Róza Ádány, Judit Laki

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Many recent data indicate that some alleles encoded in the central major histocompatibility complex (MHC) region (Class III) of short arm of chromosome 6 may modify the risk of cancer development. Therefore we determined 4 single nucleotide polymorphisms (SNPs) of this region (TNF-α -308 G > A, RAGE -429 T > C, HSP70-2 -1267 A > G, LTA 252 A > G) in genomic DNA samples from 183 Hungarian patients with colorectal cancer and 141 age matched control subjects representing the Hungarian population of the same age and gender. No significant differences were found in either SNP tested. When, however, three- or fourlocus haplotypes consisting of known constituents of the so-called 8.1 ancestral haplotype (8.1AH) were considered, marked differences were observed. Frequency of TNF-α -308A, RAGE -429C, HSP70-2 -1267G, LTA 252G (8.1AH) haplotype was significantly (p = 0.006) more frequent (19.1%) among patients than in the controls (7.7%). Age- and gender-adjusted ratio of the 8.1AH carriers vs. non-carriers to have colorectal cancer was 2.514 (1.130-5.594). This risk was higher in ≤67 years old subjects (4.073 (1.317-12.596)) and in females (3.771 (1.302-10.927). These findings - consistent with similar recent results with ovarian cancer - indicate that carriers of the 8.1AH, encoding for an altered immune response and known to be associated with alterations of several immune functions and autoimmune diseases have an increased risk for some cancer types. These findings may contribute to better understanding how the defense mechanisms against tumors could be enhanced/strengthened.

Original languageEnglish
Pages (from-to)1744-1748
Number of pages5
JournalInternational Journal of Cancer
Volume121
Issue number8
DOIs
Publication statusPublished - Oct 15 2007

Keywords

  • 8.1 Haplotype
  • Colorectal cancer
  • LTA
  • MHC
  • Rage
  • TNF
  • hsp70

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The 8.1 ancestral MHC haplotype is strongly associated with colorectal cancer risk'. Together they form a unique fingerprint.

  • Cite this