The -509 C/T genotype of TGFβ1 might contribute to the pathogenesis of benign airway stenosis

László Rovó, M. Széll, Zsolt Bella, Anita Korsós, L. Kemény, J. Jóri

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Benign airway stenosis (BAS) is one of the most severe complications of endotracheal intubation. The aim of this pilot study was to compare the frequencies of four polymorphisms of the transforming growth factor (TGF) β1 gene in patients with BAS due to endotracheal intubation (n = 36) and a control group of intensive care patients who had also undergone endotracheal intubation but did not present BAS (n = 30). One of the studied polymorphisms, the -509 C/T, demonstrated a differential genotype distribution between the affected and the control population: the ratio of heterozygous mutants was significantly (P = 0.0116) higher among the control patients. These data suggest a protective function of the frequent heterozygous C/T genotype against BAS; alternatively, the C/C genotype might be a susceptibility factor for BAS (OR 4.5; 95% CI 1.5123-13.3902). Our findings suggest that, besides other iatrogenic factors, a genetic predisposition might contribute to the pathogenesis of BAS.

Original languageEnglish
Pages (from-to)441-443
Number of pages3
JournalOtolaryngology - Head and Neck Surgery
Volume142
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Pathologic Constriction
Genotype
Intratracheal Intubation
Transforming Growth Factors
Critical Care
Genetic Predisposition to Disease
Control Groups
Population
Genes

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

The -509 C/T genotype of TGFβ1 might contribute to the pathogenesis of benign airway stenosis. / Rovó, László; Széll, M.; Bella, Zsolt; Korsós, Anita; Kemény, L.; Jóri, J.

In: Otolaryngology - Head and Neck Surgery, Vol. 142, No. 3, 03.2010, p. 441-443.

Research output: Contribution to journalArticle

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AU - Kemény, L.

AU - Jóri, J.

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