The 5-HT(1A) agonist 8-OH-DPAT increases the number of spike-wave discharges in a genetic rat model of absence epilepsy

Katalin Gerber, Janos Filakovszky, Peter Halasz, Gyorgy Bagdy

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The effects of the 5-HT(1A) receptor agonist 8-hydroxy-2-(di-n- propylamino)-tetralin (8-OH-DPAT) on the epileptiform activity has been investigated in adult WAG/RIJ rats. Either intraperitoneal (0.1-0.5 mg/kg) or intracerebroventricular (2-20 μg/rat) administration of 8-OH-DPAT caused marked, dose-dependent increases in the number and mean cumulative duration of spike-wave discharges. These effects were attenuated by NAN-190, a 5- HT(1A) receptor antagonist. These data indicate that serotonergic system regulates the epileptiform activity in this genetic model of human absence epilepsy.

Original languageEnglish
Pages (from-to)243-245
Number of pages3
JournalBrain research
Volume807
Issue number1-2
DOIs
Publication statusPublished - Oct 5 1998

Keywords

  • 5-HT(1A) receptor
  • 8-hydrox-2-(di-n-propylamin)- tetralin (8-OH-DPAT)
  • Absence epilepsy
  • Serotonin
  • Spike-wave discharge
  • WAG/RIJ rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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