Thalamocortical connectivity in major depressive disorder

Elliot C. Brown, D. Clark, Stefanie Hassel, Glenda MacQueen, Rajamannar Ramasubbu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background Major Depressive Disorder (MDD) is highly prevalent and potentially devastating, with widespread aberrations in brain activity. Thalamocortical networks are a potential candidate marker for psychopathology in MDD, but have not yet been thoroughly investigated. Here we examined functional connectivity between major cortical areas and thalamus. Method Resting-state fMRI from 54 MDD patients and 40 healthy controls were collected. The cortex was segmented into six regions of interest (ROIs) consisting of frontal, temporal, parietal, and occipital lobes and pre-central and post-central gyri. BOLD signal time courses were extracted from each ROI and correlated with voxels in thalamus, while removing signals from every other ROI. Results Our main findings showed that MDD patients had predominantly increased connectivity between medial thalamus and temporal areas, and between medial thalamus and somatosensory areas. Furthermore, a positive correlation was found between thalamo-temporal connectivity and severity of symptoms. Limitations Most of the patients in this study were not medication naïve and therefore we cannot rule out possible long-term effects of antidepressant use on the findings. Conclusion The abnormal connectivity between thalamus and temporal, and thalamus and somatosensory regions may represent impaired cortico-thalamo-cortical modulation underlying emotional, and sensory disturbances in MDD. In the context of similar abnormalities in thalamocortical systems across major psychiatric disorders, thalamocortical dysconnectivity could be a reliable transdiagnostic marker.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalJournal of Affective Disorders
Volume217
DOIs
Publication statusPublished - Aug 1 2017

Fingerprint

Major Depressive Disorder
Thalamus
Occipital Lobe
Parietal Lobe
Affective Symptoms
Somatosensory Cortex
Frontal Lobe
Temporal Lobe
Psychopathology
Antidepressive Agents
Psychiatry
Magnetic Resonance Imaging
Brain

Keywords

  • Depression
  • FMRI
  • Neuroimaging

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Thalamocortical connectivity in major depressive disorder. / Brown, Elliot C.; Clark, D.; Hassel, Stefanie; MacQueen, Glenda; Ramasubbu, Rajamannar.

In: Journal of Affective Disorders, Vol. 217, 01.08.2017, p. 125-131.

Research output: Contribution to journalArticle

Brown, Elliot C. ; Clark, D. ; Hassel, Stefanie ; MacQueen, Glenda ; Ramasubbu, Rajamannar. / Thalamocortical connectivity in major depressive disorder. In: Journal of Affective Disorders. 2017 ; Vol. 217. pp. 125-131.
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