Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation

Melinda Cservenák, Éva R. Szabó, I. Bodnár, András Lékó, M. Palkóvits, György M. Nagy, Ted B. Usdin, A. Dobolyi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Nursing has important physiological and psychological consequences on mothers during the postpartum period. Tuberoinfundibular peptide of 39 residues (TIP39) may contribute to its effects on prolactin release and maternal motivation. Since TIP39-containing fibers and the receptor for TIP39, the parathyroid hormone 2 receptor (PTH2 receptor) are abundant in the arcuate nucleus and the medial preoptic area, we antagonized TIP39 action locally to reveal its actions. Mediobasal hypothalamic injection of a virus encoding an antagonist of the PTH2 receptor markedly decreased basal serum prolactin levels and the suckling-induced prolactin release. In contrast, injecting this virus into the preoptic area had no effect on prolactin levels, but did dampen maternal motivation, judged by reduced time in a pup-associated cage during a place preference test. In support of an effect of TIP39 on maternal motivation, we observed that TIP39 containing fibers and terminals had the same distribution within the preoptic area as neurons expressing Fos in response to suckling. Furthermore, TIP39 terminals closely apposed the plasma membrane of 82% of Fos-ir neurons. Retrograde tracer injected into the arcuate nucleus and the medial preoptic area labeled TIP39 neurons in the posterior intralaminar complex of the thalamus (PIL), indicating that these cells but not other groups of TIP39 neurons project to these hypothalamic regions. We also found that TIP39 mRNA levels in the PIL markedly increased around parturition and remained elevated throughout the lactation period, demonstrating the availability of the peptide in postpartum mothers. Furthermore, suckling, but not pup exposure without physical contact, increased Fos expression by PIL TIP39 neurons. These results indicate that suckling activates TIP39 neurons in the PIL that affect prolactin release and maternal motivation via projections to the arcuate nucleus and the preoptic area, respectively.

Original languageEnglish
Pages (from-to)3070-3084
Number of pages15
JournalPsychoneuroendocrinology
Volume38
Issue number12
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Neuropeptides
Lactation
Nursing
Mothers
Preoptic Area
Prolactin
Neurons
Arcuate Nucleus of Hypothalamus
Receptor, Parathyroid Hormone, Type 2
Postpartum Period
tuberoinfundibular peptide 39
Viruses
Thalamus
Cell Membrane
Parturition
Psychology
Messenger RNA
Peptides
Injections

Keywords

  • Ascending neuronal pathway
  • Brain circuitry
  • Hypothalamus
  • Maternal behavior
  • Preoptic area
  • Prolactin release
  • Rat dams
  • Suckling

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems

Cite this

Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. / Cservenák, Melinda; Szabó, Éva R.; Bodnár, I.; Lékó, András; Palkóvits, M.; Nagy, György M.; Usdin, Ted B.; Dobolyi, A.

In: Psychoneuroendocrinology, Vol. 38, No. 12, 12.2013, p. 3070-3084.

Research output: Contribution to journalArticle

Cservenák, Melinda ; Szabó, Éva R. ; Bodnár, I. ; Lékó, András ; Palkóvits, M. ; Nagy, György M. ; Usdin, Ted B. ; Dobolyi, A. / Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. In: Psychoneuroendocrinology. 2013 ; Vol. 38, No. 12. pp. 3070-3084.
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AU - Palkóvits, M.

AU - Nagy, György M.

AU - Usdin, Ted B.

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