Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO8Pd12(PO4)8]12- (M = SnIV, PbIV)

Peng Yang, Tian Ma, Zhongling Lang, Sonja Misirlic-Dencic, Andjelka M. Isakovic, Attila Bényei, Mirjana B. Čolović, Ivanka Markovic, Danijela Z. Krstić, Josep M. Poblet, Zhengguo Lin, Ulrich Kortz

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Abstract

The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)8]12- (M = SnIV, PbIV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.

Original languageEnglish
Pages (from-to)11294-11299
Number of pages6
JournalInorganic Chemistry
Volume58
Issue number17
DOIs
Publication statusPublished - Sep 3 2019

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Cite this

Yang, P., Ma, T., Lang, Z., Misirlic-Dencic, S., Isakovic, A. M., Bényei, A., Čolović, M. B., Markovic, I., Krstić, D. Z., Poblet, J. M., Lin, Z., & Kortz, U. (2019). Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO8Pd12(PO4)8]12- (M = SnIV, PbIV). Inorganic Chemistry, 58(17), 11294-11299. https://doi.org/10.1021/acs.inorgchem.9b01129