Tetanus toxoid and congenital abnormalities

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28 Citations (Scopus)


Objective: To study the human teratogenic potential of tetanus vaccination during pregnancy. Methods: Pair analysis of cases with congenital abnormalities and matched healthy controls was performed in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. Results: Of 35 727 pregnant women who had babies without any defects in the study period (control group), 33 (0.09%) were vaccinated with tetanus. Of 21563 Pregnant women who had offspring with congenital abnormalities, 25 (0.12%) had tetanus vaccination. This difference was not significant (P = 0.39). The case-control pair analysis confirmed the safety of tetanus vaccination during pregnancy; particularly in the second and third months of gestation, i.e. during the critical period for congenital abnormalities. Conclusion: Tetanus vaccination during pregnancy appears not be teratogenic to the fetus. Thus, there is no contraindication, if the use of tetanus toxoid is necessary during pregnancy.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Issue number3
Publication statusPublished - Mar 1 1999


  • Case-control analysis
  • Congenital abnormalities
  • Pregnancy
  • Tetanus vaccination

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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