Tisacid szuszpenzió és tabletta savkötö képességének vizsgálata intragasztrikus pH-méréssel hiperacid betegekben.

Translated title of the contribution: Testing the acid-binding capacity of Tisacid suspension and tablets by intragastric pH determination in patients with hyperacidity

B. Hunyady, A. Ciráki, A. Vińcze, M. Garamszegi, L. Nagy, T. Jávor

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of a Hungarian Al-Mg-containing drug, called Tisacid was studied using of 2.0, 1.0 and 0.5 gram doses. Two administration forms, suspension and tablet were compared. Ten informed, adult hyperacid volunteers were included into the program and three times 5-hour intragastric pH-metry was carried out in a randomized, self-controlled open clinical study (Control, after administration of tablet or suspension). Both forms were found effective in gastric acid reduction at doses of 2.0 and 1.0 g. Tisacid suspension revealed a more pronounced efficacy at the dose of 2.0 g in comparison to the same dose of tablet form. The 0.5 g dose seemed insufficient in reduction of gastric acidity in hyperacid patients applied in tablet or suspension forms. The authors emphasize the role of continuous intragastric pH-metry in clinical practice and investigation of antacids and antisecretory drugs.

Translated title of the contributionTesting the acid-binding capacity of Tisacid suspension and tablets by intragastric pH determination in patients with hyperacidity
Original languageHungarian
Pages (from-to)1353-1356
Number of pages4
JournalOrvosi hetilap
Volume135
Issue number25
Publication statusPublished - Jun 19 1994

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Testing the acid-binding capacity of Tisacid suspension and tablets by intragastric pH determination in patients with hyperacidity'. Together they form a unique fingerprint.

  • Cite this