Testing of the structure of macromolecular polymer films containing solid active pharmaceutical ingredient (API) particles

É Bölcskei, K. Süvegh, T. Marek, G. Regdon, K. Pintye-Hódi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The aim of the present study was to investigate the structure of free films of Eudragit® L 30D-55 containing different concentrations (0%, 1% or 5%) of diclofenac sodium by positron annihilation spectroscopy. The data revealed that the size of the free-volume holes and the lifetimes of ortho-positronium atoms decreased with increase of the API concentration. Films containing 5% of the API exhibited a different behavior during storage (17°C, 65% relative humidity (RH)) in consequence of the uptake of water from the air.

Original languageEnglish
Pages (from-to)799-802
Number of pages4
JournalRadiation Physics and Chemistry
Volume80
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

ingredients
polymers
positronium
positron annihilation
humidity
sodium
life (durability)
air
water
spectroscopy
atoms

Keywords

  • Diclofenac sodium
  • Eudragit L 30D-55
  • Polymer films
  • Positron annihilation spectroscopy

ASJC Scopus subject areas

  • Radiation

Cite this

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abstract = "The aim of the present study was to investigate the structure of free films of Eudragit{\circledR} L 30D-55 containing different concentrations (0{\%}, 1{\%} or 5{\%}) of diclofenac sodium by positron annihilation spectroscopy. The data revealed that the size of the free-volume holes and the lifetimes of ortho-positronium atoms decreased with increase of the API concentration. Films containing 5{\%} of the API exhibited a different behavior during storage (17°C, 65{\%} relative humidity (RH)) in consequence of the uptake of water from the air.",
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AU - Bölcskei, É

AU - Süvegh, K.

AU - Marek, T.

AU - Regdon, G.

AU - Pintye-Hódi, K.

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AB - The aim of the present study was to investigate the structure of free films of Eudragit® L 30D-55 containing different concentrations (0%, 1% or 5%) of diclofenac sodium by positron annihilation spectroscopy. The data revealed that the size of the free-volume holes and the lifetimes of ortho-positronium atoms decreased with increase of the API concentration. Films containing 5% of the API exhibited a different behavior during storage (17°C, 65% relative humidity (RH)) in consequence of the uptake of water from the air.

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KW - Polymer films

KW - Positron annihilation spectroscopy

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