Testing of pesticide toxicity in tissue culture

I. Dési, G. Dura, J. Szlobodnyik, I. Csuka

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of pesticides on cell growth and on the cell layer was examined. The pesticides under study had a similar toxicity for the cell suspension and for the cell layer. Vital staining of the cells allowed a more sensitive determination of the cytotoxic concentrations than did the studies on cell morphology without staining. No correlation was found between the cytotoxic concentrations and LD50 values of mammals. The results were compared with those of earlier experiments on rats in which methods of general toxicology and neurotoxicology were applied. Of the 8 compounds tested, in 6 the tissue culture method proved even more sensitive than did the functional neurotoxicological tests. It is suggested that the in vitro method with cultured cells should be used to complement in vivo functional toxicological procedures.

Original languageEnglish
Pages (from-to)1053-1066
Number of pages14
JournalJournal of Toxicology and Environmental Health
Volume2
Issue number5
Publication statusPublished - 1977

Fingerprint

Tissue culture
Pesticides
Toxicity
Cells
Testing
Mammals
Cell growth
Toxicology
Rats
Suspensions
Staining and Labeling
Lethal Dose 50
Cultured Cells
Experiments
Growth

ASJC Scopus subject areas

  • Toxicology
  • Pollution

Cite this

Dési, I., Dura, G., Szlobodnyik, J., & Csuka, I. (1977). Testing of pesticide toxicity in tissue culture. Journal of Toxicology and Environmental Health, 2(5), 1053-1066.

Testing of pesticide toxicity in tissue culture. / Dési, I.; Dura, G.; Szlobodnyik, J.; Csuka, I.

In: Journal of Toxicology and Environmental Health, Vol. 2, No. 5, 1977, p. 1053-1066.

Research output: Contribution to journalArticle

Dési, I, Dura, G, Szlobodnyik, J & Csuka, I 1977, 'Testing of pesticide toxicity in tissue culture', Journal of Toxicology and Environmental Health, vol. 2, no. 5, pp. 1053-1066.
Dési, I. ; Dura, G. ; Szlobodnyik, J. ; Csuka, I. / Testing of pesticide toxicity in tissue culture. In: Journal of Toxicology and Environmental Health. 1977 ; Vol. 2, No. 5. pp. 1053-1066.
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