Elemi vizuális funkciók vizsgálata az antipszichotikumok által elP6dézett extrapyramidalis mellékhatások követésében.

Translated title of the contribution: Testing basic visual functions in the evaluation of extrapyramidal side effects of antipsychotic agents

S. Kéri, A. Antal, G. Szekeres, I. Szendi, Z. Kovács, Z. Janka, G. Benedek

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

One of the cornerstones of antipsychotic therapy is the evaluation of the effective dose that cause minimal extrapyramidal side effects. It is known that the visual system (e. g. the retina) contains dopaminergic cells similarly to the striatum where dopaminergic blockade is crucial in the induction of extrapyramidal symptoms. This rises the possibility that striatal functions can be tested by the evaluation of certain visual functions. This study compared the visual contrast-sensitivity of 20 schizophrenic patients on antipsychotic medication (9 patients were on risperidone, 9 on haloperidol, and 1-1 on zuclopenthixol and fluanxol treatment) to that of normal control subjects, and found significant impairment in the former group. The contrast-sensitivity impairments correlated with the severity of extrapyramidal symptoms. These results suggest that contrast-sensitivity measurements can be useful in the evaluation of neuroleptic threshold in the clinical practice.

Original languageHungarian
Pages (from-to)235-238
Number of pages4
JournalOrvosi Hetilap
Volume139
Issue number5
Publication statusPublished - Feb 1 1998

Fingerprint

Contrast Sensitivity
Antipsychotic Agents
Clopenthixol
Flupenthixol
Corpus Striatum
Risperidone
Haloperidol
Retina
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Elemi vizuális funkciók vizsgálata az antipszichotikumok által elP6dézett extrapyramidalis mellékhatások követésében. / Kéri, S.; Antal, A.; Szekeres, G.; Szendi, I.; Kovács, Z.; Janka, Z.; Benedek, G.

In: Orvosi Hetilap, Vol. 139, No. 5, 01.02.1998, p. 235-238.

Research output: Contribution to journalArticle

@article{521cd73131d045359615e0cf9adef9be,
title = "Elemi vizu{\'a}lis funkci{\'o}k vizsg{\'a}lata az antipszichotikumok {\'a}ltal elP6d{\'e}zett extrapyramidalis mell{\'e}khat{\'a}sok k{\"o}vet{\'e}s{\'e}ben.",
abstract = "One of the cornerstones of antipsychotic therapy is the evaluation of the effective dose that cause minimal extrapyramidal side effects. It is known that the visual system (e. g. the retina) contains dopaminergic cells similarly to the striatum where dopaminergic blockade is crucial in the induction of extrapyramidal symptoms. This rises the possibility that striatal functions can be tested by the evaluation of certain visual functions. This study compared the visual contrast-sensitivity of 20 schizophrenic patients on antipsychotic medication (9 patients were on risperidone, 9 on haloperidol, and 1-1 on zuclopenthixol and fluanxol treatment) to that of normal control subjects, and found significant impairment in the former group. The contrast-sensitivity impairments correlated with the severity of extrapyramidal symptoms. These results suggest that contrast-sensitivity measurements can be useful in the evaluation of neuroleptic threshold in the clinical practice.",
author = "S. K{\'e}ri and A. Antal and G. Szekeres and I. Szendi and Z. Kov{\'a}cs and Z. Janka and G. Benedek",
year = "1998",
month = "2",
day = "1",
language = "Hungarian",
volume = "139",
pages = "235--238",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "5",

}

TY - JOUR

T1 - Elemi vizuális funkciók vizsgálata az antipszichotikumok által elP6dézett extrapyramidalis mellékhatások követésében.

AU - Kéri, S.

AU - Antal, A.

AU - Szekeres, G.

AU - Szendi, I.

AU - Kovács, Z.

AU - Janka, Z.

AU - Benedek, G.

PY - 1998/2/1

Y1 - 1998/2/1

N2 - One of the cornerstones of antipsychotic therapy is the evaluation of the effective dose that cause minimal extrapyramidal side effects. It is known that the visual system (e. g. the retina) contains dopaminergic cells similarly to the striatum where dopaminergic blockade is crucial in the induction of extrapyramidal symptoms. This rises the possibility that striatal functions can be tested by the evaluation of certain visual functions. This study compared the visual contrast-sensitivity of 20 schizophrenic patients on antipsychotic medication (9 patients were on risperidone, 9 on haloperidol, and 1-1 on zuclopenthixol and fluanxol treatment) to that of normal control subjects, and found significant impairment in the former group. The contrast-sensitivity impairments correlated with the severity of extrapyramidal symptoms. These results suggest that contrast-sensitivity measurements can be useful in the evaluation of neuroleptic threshold in the clinical practice.

AB - One of the cornerstones of antipsychotic therapy is the evaluation of the effective dose that cause minimal extrapyramidal side effects. It is known that the visual system (e. g. the retina) contains dopaminergic cells similarly to the striatum where dopaminergic blockade is crucial in the induction of extrapyramidal symptoms. This rises the possibility that striatal functions can be tested by the evaluation of certain visual functions. This study compared the visual contrast-sensitivity of 20 schizophrenic patients on antipsychotic medication (9 patients were on risperidone, 9 on haloperidol, and 1-1 on zuclopenthixol and fluanxol treatment) to that of normal control subjects, and found significant impairment in the former group. The contrast-sensitivity impairments correlated with the severity of extrapyramidal symptoms. These results suggest that contrast-sensitivity measurements can be useful in the evaluation of neuroleptic threshold in the clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=17344379695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17344379695&partnerID=8YFLogxK

M3 - Article

C2 - 9489377

AN - SCOPUS:17344379695

VL - 139

SP - 235

EP - 238

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 5

ER -