The possibility of ternary complex formation has been studied in the Al(III)-adenosine-5′-phosphate (AMP, ADP, and ATP)-ligand B (oxalic acid, lactic acid, and malic acid) systems by pH-potentiometric and 31P NMR methods. Formation of ternary complexes AlABH and AlAB is favored in all systems in the acidic pH range. Under physiological conditions at μmolar Al3+ concentrations and at high ligand excess, Al(III) is bound mainly to the nucleotides: almost exclusively in the presence of the relatively weak bidentate Al(III) binder oxalic acid and lactic acid, and about 30% in the presence of the much stronger tridentate-coordinating molecule, malic acid.
ASJC Scopus subject areas
- Inorganic Chemistry