Ternary complex formation between Al(III)-adenosine-5′-phosphates and carboxylic acid derivatives

Tamás Kiss, Imre Sóvágó, R. Bruce Martin, Jouni Pursiainen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The possibility of ternary complex formation has been studied in the Al(III)-adenosine-5′-phosphate (AMP, ADP, and ATP)-ligand B (oxalic acid, lactic acid, and malic acid) systems by pH-potentiometric and 31P NMR methods. Formation of ternary complexes AlABH and AlAB is favored in all systems in the acidic pH range. Under physiological conditions at μmolar Al3+ concentrations and at high ligand excess, Al(III) is bound mainly to the nucleotides: almost exclusively in the presence of the relatively weak bidentate Al(III) binder oxalic acid and lactic acid, and about 30% in the presence of the much stronger tridentate-coordinating molecule, malic acid.

Original languageEnglish
Pages (from-to)53-65
Number of pages13
JournalJournal of Inorganic Biochemistry
Volume55
Issue number1
DOIs
Publication statusPublished - 1994

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Oxalic Acid
Adenosine Monophosphate
Carboxylic Acids
Lactic Acid
Ligands
Derivatives
Adenosine Diphosphate
Binders
Nucleotides
Adenosine Triphosphate
Nuclear magnetic resonance
Molecules
malic acid
adenosine-5'-carboxylic acid

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Ternary complex formation between Al(III)-adenosine-5′-phosphates and carboxylic acid derivatives. / Kiss, Tamás; Sóvágó, Imre; Martin, R. Bruce; Pursiainen, Jouni.

In: Journal of Inorganic Biochemistry, Vol. 55, No. 1, 1994, p. 53-65.

Research output: Contribution to journalArticle

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