Ternary complex formation between Al(III)-adenosine-5′-phosphates and carboxylic acid derivatives

Tamás Kiss, Imre Sóvágó, R. Bruce Martin, Jouni Pursiainen

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Abstract

The possibility of ternary complex formation has been studied in the Al(III)-adenosine-5′-phosphate (AMP, ADP, and ATP)-ligand B (oxalic acid, lactic acid, and malic acid) systems by pH-potentiometric and 31P NMR methods. Formation of ternary complexes AlABH and AlAB is favored in all systems in the acidic pH range. Under physiological conditions at μmolar Al3+ concentrations and at high ligand excess, Al(III) is bound mainly to the nucleotides: almost exclusively in the presence of the relatively weak bidentate Al(III) binder oxalic acid and lactic acid, and about 30% in the presence of the much stronger tridentate-coordinating molecule, malic acid.

Original languageEnglish
Pages (from-to)53-65
Number of pages13
JournalJournal of Inorganic Biochemistry
Volume55
Issue number1
DOIs
Publication statusPublished - Jul 1994

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ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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