Ternary β-cyclodextrin complexes as models of allosteric effects

Ágnes Buvári-Barcza, A. Csámpai, Lajos Barcza

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Two guests reacting with cyclodextrins (CDs) may form ternary complexes, in addition to the common competition of 1:1 complexes. One of the guests can really be included into the cavity of the CD, while the second guest molecule is either inserted close to the first one or attached to the outer surface of the supramolecule by H-bonding. There is a further possibility when the included guest bears a substituent outside the cavity and the second guest can interact with it. The properties of the ternary species formed are highly influenced by the solely (or primarily) included guest. The changes are attributed to the altered properties of the hydrophilic domain of the CD. The phenomena can be proved by NMR data obtained for some binary systems of β-CD inclusion complexes and acetic acid and by the stability constants of the ternary complexes formed. Allosteric effects as well as coenzyme/apoenzyme/substrate interactions could be well modelled by these types of CD complexes.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalJournal of Inclusion Phenomena
Volume42
Issue number3-4
DOIs
Publication statusPublished - 2002

Fingerprint

cyclodextrins
Cyclodextrins
coenzymes
cavities
bears
acetic acid
inclusions
nuclear magnetic resonance
acids
Apoenzymes
apoproteins
hydrogen bonding
Coenzymes
molecules
Acetic Acid
interactions
Nuclear magnetic resonance
Molecules
Substrates

Keywords

  • β-cyclodextrin
  • Allosteric effect
  • Allosteric enzyme systems
  • Formation constants
  • Solubility changes
  • Ternary complexes

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Ternary β-cyclodextrin complexes as models of allosteric effects. / Buvári-Barcza, Ágnes; Csámpai, A.; Barcza, Lajos.

In: Journal of Inclusion Phenomena, Vol. 42, No. 3-4, 2002, p. 209-212.

Research output: Contribution to journalArticle

Buvári-Barcza, Ágnes ; Csámpai, A. ; Barcza, Lajos. / Ternary β-cyclodextrin complexes as models of allosteric effects. In: Journal of Inclusion Phenomena. 2002 ; Vol. 42, No. 3-4. pp. 209-212.
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