Termini of Salmonella flagellin are disordered and become organized upon polymerization into flagellar filament

S. I. Aizawa, F. Vonderviszt, R. Ishima, K. Akasaka

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The terminal regions of Salmonella flagellin are essential for polymerization to form the flagellar filament. It has recently been suggested, on the basis of results from circular dichroism spectroscopy and scanning calorimetry, that these regions are disordered in solution. We report here direct evidence for disorder and mobility in the terminal regions of flagellin using 400 MHz proton nuclear magnetic resonance (n.m.r.) spectroscopy. Comparison of the n.m.r. spectra of monomeric and polymeric flagellin shows that the terminal regions become organized when polymerized to form the filament.

Original languageEnglish
Pages (from-to)673-677
Number of pages5
JournalJournal of molecular biology
Volume211
Issue number4
DOIs
Publication statusPublished - Feb 20 1990

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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