Teratological surveillance of oral contraceptive use in early pregnancy

A. E. Czeizel, J. Vass

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Abstract

The teratogenic potential of oral contraceptives during pregnancy was evaluated in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1982. Of 32,804 negative control infants without congenital abnormalities, 127 (0.4%) had mothers with oral contraceptive use. Of 19,176 index cases with congenital abnormalities, 131 (0.7%) had mothers who used oral contraceptives. The analysis of specific oral contraceptive formulations in index ease-matched control pairs did not indicate a higher use of specific oral contraceptives in all but one different congenital abnormality groups. Of seven cases with Down syndrome, 5 mothers used Bisecurin® including ethynodiol-diacetate (1 mg) and ethinyloestradiol (0.05 mg), odds ratio was 11.0 (I 95% 1.3, 91.4).

Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalAdvances in Contraceptive Delivery Systems
Volume12
Issue number1-2
Publication statusPublished - Jan 1 1996

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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