Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2

Jessica Cusato, Andrea Calcagno, Amedeo De Nicolò, K. Mogyorósi, Antonio D'Avolio, Giovanni Di Perri, Stefano Bonora

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tenofovir-associated renal toxicity is influenced by several factors, including plasma exposure and genetic variants in transporter-encoding genes. Tenofovir plasma exposure has been associated with a polymorphism in SLC28A2 gene (encoding the concentrative nucleoside transporter 2, CNT2): particularly, SLC28A2 124 CT/TT genotype patients show higher plasma tenofovir concentrations, compared to CC group. In literature, substrate studies are lacking; for this reason, our aim was to understand if tenofovir and tenofovir-alafenamide are CNT2 substrates. We performed an in vitro study using CNT2 expressing MDCKII cells. We observed that tenofovir and tenofovir-alafenamide are not substrates of CNT2. Tenofovir-alafenamide influx pathway remains to be clarified.

Original languageEnglish
JournalDiagnostic Microbiology and Infectious Disease
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • CNT2
  • HAART
  • HIV
  • Renal toxicity
  • SLC28A2
  • TAF
  • TDF

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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