Tenascin Expression and Angiogenesis in breast cancer

Anna Mária Tökés, Eszter Hortoványi, Janina Kulka, Márta Jäckel, Tibor Kerényi, Anna Kádár

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The expression and the distribution of tenascin as well as the extent of blood vessel formation (angiogenesis) were investigated in 70 invasive human breast carcinomas. Formalin-fixed, paraffin-embedded specimens were stained with monoclonal antibody against tenascin-C (DAKO and Biogenex). Anti-CD31 antibody (Biogenex), an acknowledged marker of stromal angiogenesis, was used to detect endothelial cells. Tenascin immunostaining was positive in the tumours around the persisting normal ducts, around tumour-cell nests, in the neostroma, in some tumour cells, and it was found in or around vascular channels. Tumour vascularity was assessed by quantitative vascular grading (Chalkley point count) and was related to the localization and intensity of tenascin immunoreactivity. 19 tumours (27.1%) were scored as low, 35 (50%) as medium, and 16 (22.9%) as having a high vascular grade. The positive correlation between the vascular grade and the tenascin immunopositivity in tumour stroma was observed. Our results suggest that tenascin expression may be associated with endothelial cell activation and may play an important role in tumour angiogenesis.

Original languageEnglish
Pages (from-to)821-828
Number of pages8
JournalPathology Research and Practice
Volume195
Issue number12
DOIs
Publication statusPublished - Jan 1 1999

Keywords

  • Angiogenesis
  • Breast cancer
  • Tenascin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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