Temporal sequence of mutation for 6-thioguanine resistance in synchronised Chinese hamster cells

I. Raskó, K. Burg, L. Dallmann

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Abstract

The temporal sequence of mutation to 6-thioguanine resistance was studied in Chinese hamster ovary cells synchronised in S phase. The number of resistant mutants induced following exposure to pulses of bromodeoxyuridine and subsequent selection was significantly greater if BUdR pulses were administered during the first, rather than the second half of S phase. The results are interpreted as indicating that the gene responsible for 6-thioguanine resistance is replicated during the first half of S phase.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalTheoretical and Applied Genetics
Volume48
Issue number4
DOIs
Publication statusPublished - Jul 1 1976

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ASJC Scopus subject areas

  • Biotechnology
  • Agronomy and Crop Science
  • Genetics

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