Temporal instability of salience network activity in migraine with aura

Dániel Veréb, Nikoletta Szabó, Bernadett Tuka, János Tajti, András Király, Péter Faragó, Krisztián Kocsis, Eszter Tóth, Bence Bozsik, Bálint Kincses, László Vécsei, Zsigmond Tamás Kincses

Research output: Contribution to journalArticle

Abstract

This study aims to investigate whether intranetwork dynamic functional connectivity and causal interactions of the salience network is altered in the interictal term of migraine. Thirty-two healthy controls, 37 migraineurs without aura, and 20 migraineurs with aura were recruited. Participants underwent a T1-weighted scan and resting-state fMRI protocol inside a 1.5T MR scanner. We obtained average spatial maps of resting-state networks using group independent component analysis, which yielded subject-specific time series through a dual regression approach. Salience network regions of interest (bilateral insulae and prefrontal cortices, dorsal anterior cingulate cortex) were obtained from the group average map through cluster-based thresholding. To describe intranetwork connectivity, average and dynamic conditional correlation was calculated. Causal interactions between the default-mode, dorsal attention, and salience network were characterised by spectral Granger's causality. Time-averaged correlation was lower between the right insula and prefrontal cortex in migraine without aura vs with aura and healthy controls (P < 0.038, P < 0.037). Variance of dynamic conditional correlation was higher in migraine with aura vs healthy controls and migraine with aura vs without aura between the right insula and dorsal anterior cingulate cortex (P < 0.011, P < 0.026), and in migraine with aura vs healthy controls between the dorsal anterior cingulate and left prefrontal cortex (P < 0.021). Causality was weaker in the <0.05 Hz frequency range between the salience and dorsal attention networks in migraine with aura (P < 0.032). Overall, migraineurs with aura exhibit more fluctuating connections in the salience network, which also affect network interactions, and could be connected to altered cortical excitability and increased sensory gain.

Original languageEnglish
Pages (from-to)856-864
Number of pages9
JournalPain
Volume161
Issue number4
DOIs
Publication statusPublished - Apr 1 2020

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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  • Cite this

    Veréb, D., Szabó, N., Tuka, B., Tajti, J., Király, A., Faragó, P., Kocsis, K., Tóth, E., Bozsik, B., Kincses, B., Vécsei, L., & Kincses, Z. T. (2020). Temporal instability of salience network activity in migraine with aura. Pain, 161(4), 856-864. https://doi.org/10.1097/j.pain.0000000000001770