Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm

Magor L. Lorincz, K. Kékesi, G. Juhász, Vincenzo Crunelli, Stuart W. Hughes

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (α) rhythm. However, how the α rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the lateral geniculate nucleus (LGN) that operate in a conventional relay-mode form two groups where the cumulative firing is subject to a cyclic suppression that is centered on the negative α rhythm peak in one group and on the positive peak in the other. This leads to an effective temporal framing of relay-mode output and results from phasic inhibition from LGN interneurons, which in turn are rhythmically excited by thalamocortical neurons that exhibit high-threshold bursts. These results provide a potential cellular substrate for linking the α rhythm to perception and further underscore the central role of inhibition in controlling spike timing during cognitively relevant brain oscillations.

Original languageEnglish
Pages (from-to)683-696
Number of pages14
JournalNeuron
Volume63
Issue number5
DOIs
Publication statusPublished - Sep 10 2009

Fingerprint

Alpha Rhythm
Geniculate Bodies
Neurons
Interneurons
Cats
Brain
Inhibition (Psychology)

Keywords

  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm. / Lorincz, Magor L.; Kékesi, K.; Juhász, G.; Crunelli, Vincenzo; Hughes, Stuart W.

In: Neuron, Vol. 63, No. 5, 10.09.2009, p. 683-696.

Research output: Contribution to journalArticle

Lorincz, Magor L. ; Kékesi, K. ; Juhász, G. ; Crunelli, Vincenzo ; Hughes, Stuart W. / Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm. In: Neuron. 2009 ; Vol. 63, No. 5. pp. 683-696.
@article{690c13d8d8d84e25ada6425a46c46f15,
title = "Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm",
abstract = "Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (α) rhythm. However, how the α rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the lateral geniculate nucleus (LGN) that operate in a conventional relay-mode form two groups where the cumulative firing is subject to a cyclic suppression that is centered on the negative α rhythm peak in one group and on the positive peak in the other. This leads to an effective temporal framing of relay-mode output and results from phasic inhibition from LGN interneurons, which in turn are rhythmically excited by thalamocortical neurons that exhibit high-threshold bursts. These results provide a potential cellular substrate for linking the α rhythm to perception and further underscore the central role of inhibition in controlling spike timing during cognitively relevant brain oscillations.",
keywords = "SYSNEURO",
author = "Lorincz, {Magor L.} and K. K{\'e}kesi and G. Juh{\'a}sz and Vincenzo Crunelli and Hughes, {Stuart W.}",
year = "2009",
month = "9",
day = "10",
doi = "10.1016/j.neuron.2009.08.012",
language = "English",
volume = "63",
pages = "683--696",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm

AU - Lorincz, Magor L.

AU - Kékesi, K.

AU - Juhász, G.

AU - Crunelli, Vincenzo

AU - Hughes, Stuart W.

PY - 2009/9/10

Y1 - 2009/9/10

N2 - Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (α) rhythm. However, how the α rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the lateral geniculate nucleus (LGN) that operate in a conventional relay-mode form two groups where the cumulative firing is subject to a cyclic suppression that is centered on the negative α rhythm peak in one group and on the positive peak in the other. This leads to an effective temporal framing of relay-mode output and results from phasic inhibition from LGN interneurons, which in turn are rhythmically excited by thalamocortical neurons that exhibit high-threshold bursts. These results provide a potential cellular substrate for linking the α rhythm to perception and further underscore the central role of inhibition in controlling spike timing during cognitively relevant brain oscillations.

AB - Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (α) rhythm. However, how the α rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the lateral geniculate nucleus (LGN) that operate in a conventional relay-mode form two groups where the cumulative firing is subject to a cyclic suppression that is centered on the negative α rhythm peak in one group and on the positive peak in the other. This leads to an effective temporal framing of relay-mode output and results from phasic inhibition from LGN interneurons, which in turn are rhythmically excited by thalamocortical neurons that exhibit high-threshold bursts. These results provide a potential cellular substrate for linking the α rhythm to perception and further underscore the central role of inhibition in controlling spike timing during cognitively relevant brain oscillations.

KW - SYSNEURO

UR - http://www.scopus.com/inward/record.url?scp=69949100709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949100709&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2009.08.012

DO - 10.1016/j.neuron.2009.08.012

M3 - Article

VL - 63

SP - 683

EP - 696

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 5

ER -