Temporal dynamics of parvalbumin-expressing axo-axonic and basket cells in the rat medial prefrontal cortex in vivo

Lema Massi, Michael Lagler, Katja Hartwich, Zsolt Borhegyi, Peter Somogyi, Thomas Klausberger

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Abstract

Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN- to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.

Original languageEnglish
Pages (from-to)16496-16502
Number of pages7
JournalJournal of Neuroscience
Volume32
Issue number46
DOIs
Publication statusPublished - Nov 14 2012

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ASJC Scopus subject areas

  • Neuroscience(all)

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